INT22337

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Context Info
Confidence 0.59
First Reported 1990
Last Reported 2008
Negated 1
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.17
Pain Relevance 4.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
hypothalamus 10
neural 4
adrenal gland 2
corticotroph 2
T-cell 2
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
mu opioid receptor 6 99.78 Very High Very High Very High
Morphine 43 99.52 Very High Very High Very High
Dynorphin 7 99.08 Very High Very High Very High
Endogenous opioid 11 96.40 Very High Very High Very High
opiate 7 94.24 High High
opioid receptor 3 92.12 High High
medulla 7 91.12 High High
Opioid 7 90.44 High High
dexamethasone 9 84.28 Quite High
Enkephalin 5 79.28 Quite High
Disease Link Frequency Relevance Heat
Eating Disorder 5 98.82 Very High Very High Very High
Body Weight 4 98.24 Very High Very High Very High
Diabetes Mellitus 10 98.08 Very High Very High Very High
Targeted Disruption 10 97.96 Very High Very High Very High
Aids-related Complex 11 92.04 High High
Hyperglycemia 2 81.60 Quite High
Stress 33 75.00 Quite High
Hyperphagia 1 75.00 Quite High
Adrenal Insufficiency 2 69.52 Quite High
Hyponatremia 5 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that in sheep, POMC mRNA levels are not reduced at the time of the preovulatory LH surge, and reduced POMC gene transcription does not appear to be part of the neural mechanism of oestrogen positive feedback in this species.
Negative_regulation (reduced) of Transcription (transcription) of POMC gene in neural
1) Confidence 0.59 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.05
In rats, proopiomelanocortin (POMC) mRNA levels in the arcuate nucleus are reduced at the time of the LH surge, and this is thought to be part of the neural mechanism of oestrogen positive feedback.
Negative_regulation (reduced) of Transcription (levels) of proopiomelanocortin in neural
2) Confidence 0.51 Published 1998 Journal J. Neuroendocrinol. Section Abstract Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.09
Proopiomelanocortin mRNA levels in ovine hypothalamus are not reduced at the time of the preovulatory luteinising hormone surge.
Neg (not) Negative_regulation (reduced) of Transcription (levels) of Proopiomelanocortin in hypothalamus
3) Confidence 0.43 Published 1998 Journal J. Neuroendocrinol. Section Title Doc Link 9792332 Disease Relevance 0 Pain Relevance 0.09
METHODS: The effect of LLLT on opioid analgesia and production was evaluated in vivo in a rat model of inflammation as well as in vitro in Jurkat cells, a human T-cell leukemia cell line. mRNA expression of the beta-endorphin precursors proopiomelanocortin and corticotrophin releasing factor was assessed by reverse transcription polymerase chain reaction.
Negative_regulation (assessed) of Transcription (expression) of beta-endorphin precursors proopiomelanocortin in T-cell
4) Confidence 0.42 Published 2007 Journal Lasers Surg Med Section Body Doc Link 18081143 Disease Relevance 0 Pain Relevance 0
In experiment 1, food restriction of 10,20,30, and 40% (g) of ad libitum intake for 14 days decreased proDynorphin (proDyn), proEnkephalin (proEnk), and proOpiomelanocortin (POMC) mRNA levels in a linear fashion relative to changes in body weight (r = 0.398, P = 0.0011; r = 0.455, P = 0.0028; r = 0.292, P = 0.0642, respectively).
Negative_regulation (decreased) of Transcription (levels) of POMC in body associated with body weight and eating disorder
5) Confidence 0.42 Published 1996 Journal Am. J. Physiol. Section Abstract Doc Link 8928900 Disease Relevance 0.64 Pain Relevance 0.33
Caloric restriction of the same diet decreases mRNA levels of proDynorphin, proEnkephalin and POMC, as well as levels of Dynorphin A1-17.
Negative_regulation (decreases) of Transcription (levels) of POMC associated with dynorphin
6) Confidence 0.41 Published 1996 Journal Brain Res. Section Abstract Doc Link 8793092 Disease Relevance 0.07 Pain Relevance 0.42
Normalization of the plasma glucose concentration in STZ-diabetic rats with exogenous insulin or phlorizin, an inhibitor of the renal tubular glucose transport, reversed the mRNA level of POMC in the adrenal gland after 4 days of treatment.
Negative_regulation (reversed) of Transcription (level) of POMC in adrenal gland associated with diabetes mellitus
7) Confidence 0.41 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11796185 Disease Relevance 0.87 Pain Relevance 0.18
Similarly in castrated, estradiol replaced female rats, the mean POMC mRNA level in the MBH was 1.36 +/- 0.19 pg/microgram RNA and decreased to 0.82 +/- 0.08 pg/microgram RNA after morphine treatment (P < 0.05). beta-EP levels were not significantly different in either study.
Negative_regulation (decreased) of Transcription (level) of POMC mRNA in MBH associated with morphine
8) Confidence 0.38 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8883945 Disease Relevance 0 Pain Relevance 0.70
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (content) of pro-opiomelanocortin in gland
9) Confidence 0.36 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
Currently, we tested the hypothesis that chronic morphine, which produces down-regulation of mu-opioid receptors, causes a down-regulation of pro-opiomelanocortin (POMC, the precursor of beta-EP) mRNA expression in female guinea pig hypothalamus.
Negative_regulation (down) of Transcription (expression) of pro-opiomelanocortin in hypothalamus associated with mu opioid receptor and morphine
10) Confidence 0.14 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645954 Disease Relevance 0.06 Pain Relevance 0.78
Proopiomelanocortin (POMC) mRNA expression: distribution and region-specific down-regulation by chronic morphine in female guinea pig hypothalamus.
Negative_regulation (down-regulation) of Transcription (expression) of Proopiomelanocortin in hypothalamus associated with morphine
11) Confidence 0.11 Published 1998 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 9645954 Disease Relevance 0 Pain Relevance 0.72
Currently, we tested the hypothesis that chronic morphine, which produces down-regulation of mu-opioid receptors, causes a down-regulation of pro-opiomelanocortin (POMC, the precursor of beta-EP) mRNA expression in female guinea pig hypothalamus.
Negative_regulation (regulation) of Transcription (expression) of pro-opiomelanocortin in hypothalamus associated with mu opioid receptor and morphine
12) Confidence 0.10 Published 1998 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 9645954 Disease Relevance 0.06 Pain Relevance 0.78
The mRNA expression of proopiomelanocortin (POMC), which is a large precursor of ACTH, is not impaired in corticotroph of CRH KO mice.
Negative_regulation (impaired) of Transcription (expression) of proopiomelanocortin in corticotroph
13) Confidence 0.03 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733102 Disease Relevance 0.39 Pain Relevance 0.08

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