INT22338

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Context Info
Confidence 0.43
First Reported 1990
Last Reported 2008
Negated 0
Speculated 2
Reported most in Abstract
Documents 11
Total Number 14
Disease Relevance 2.09
Pain Relevance 5.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
nucleus 8
amygdala 7
hypothalamus 4
gland 4
oval nucleus 3
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 29 99.84 Very High Very High Very High
cocaine 17 99.82 Very High Very High Very High
amygdala 90 99.44 Very High Very High Very High
Enkephalin 18 98.74 Very High Very High Very High
fluoxetine 13 98.64 Very High Very High Very High
noradrenaline 3 97.52 Very High Very High Very High
Morphine 12 95.64 Very High Very High Very High
Locus ceruleus 1 95.20 Very High Very High Very High
withdrawal 18 94.24 High High
tolerance 2 90.28 High High
Disease Link Frequency Relevance Heat
Anxiety Disorder 38 97.08 Very High Very High Very High
Stress 218 94.96 High High
Depression 67 79.12 Quite High
Nutritional Deficiencies 3 75.00 Quite High
Neurodegenerative Disease 16 5.00 Very Low Very Low Very Low
Cognitive Disorder 10 5.00 Very Low Very Low Very Low
Mental Disorders 6 5.00 Very Low Very Low Very Low
Death 4 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Convulsion 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In parallel with the decrease in the expression of CRF and AVP mRNAs in the PVN, there was a pronounced decrease in noradrenaline turnover and in the release of corticosterone in the morphine-pelleted rats.
Negative_regulation (decrease) of Transcription (expression) of CRF in PVN associated with noradrenaline and morphine
1) Confidence 0.43 Published 2003 Journal J. Neuroendocrinol. Section Abstract Doc Link 12716409 Disease Relevance 0 Pain Relevance 0.95
A 6-hydroxydopamine lesion of the mesostriatal dopamine system decreases the expression of corticotropin releasing hormone and neurotensin mRNAs in the amygdala and bed nucleus of the stria terminalis.
Negative_regulation (decreases) of Transcription (expression) of corticotropin releasing hormone in amygdala associated with dopamine, enkephalin and amygdala
2) Confidence 0.43 Published 2002 Journal Brain Res. Section Title Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.51
Levels of CRH and neurotensin mRNAs were decreased on the lesioned side in the CEA and oval nucleus of the BST (BSTov) relative to the intact side and to unoperated controls.
Negative_regulation (decreased) of Transcription (Levels) of CRH in oval nucleus associated with amygdala
3) Confidence 0.43 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.67
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (content) of CRF in gland
4) Confidence 0.43 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
In-situ hybridization with synthetic oligonucleotide probes was used to determine the mRNA content of corticotrophin-releasing factor (CRF) and proenkephalin A mRNA in the paraventricular nucleus, and of pro-opiomelanocortin (POMC) mRNA in the anterior pituitary gland of male rats immediately after, and during recovery from, chronic high-dose prednisolone treatment.
Spec (determine) Negative_regulation (determine) of Spec (determine) Transcription (content) of corticotrophin-releasing factor in gland
5) Confidence 0.43 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.07 Pain Relevance 0.07
Fluoxetine (10 mg/kg) given daily for 8 weeks, but not 2 weeks, significantly decreased levels of corticotropin-releasing hormone (CRH) mRNA by 22% in the paraventricular nucleus (PVN) of the hypothalamus and tyrosine hydroxylase (TH) mRNA by 23% in the locus coeruleus.
Negative_regulation (decreased) of Transcription (levels) of CRH in hypothalamus associated with locus ceruleus and fluoxetine
6) Confidence 0.42 Published 2003 Journal Neuropsychopharmacology Section Abstract Doc Link 12865894 Disease Relevance 0.08 Pain Relevance 0.41
In addition to its glutamatergic modulation, tianeptine reduces the expression of corticotropin-releasing hormone (CRH) mRNA in the amygdala and the bed nucleus of the stria terminalis (BNST), a brain region that is highly innervated by amygdala fibers [86].
Negative_regulation (reduces) of Transcription (expression) of corticotropin-releasing hormone in amygdala associated with amygdala
7) Confidence 0.41 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.82 Pain Relevance 0.69
This blunting of HPA axis activity in response to cocaine is associated with a cocaine-induced reduction of corticotropin-releasing hormone (CRH) mRNA level in the hypothalamus.
Negative_regulation (reduction) of Transcription (level) of CRH in hypothalamus associated with cocaine
8) Confidence 0.41 Published 2003 Journal Brain Res. Section Abstract Doc Link 12576179 Disease Relevance 0 Pain Relevance 0.51
In addition to its glutamatergic modulation, tianeptine reduces the expression of corticotropin-releasing hormone (CRH) mRNA in the amygdala and the bed nucleus of the stria terminalis (BNST), a brain region that is highly innervated by amygdala fibers [86].
Negative_regulation (reduces) of Transcription (expression) of CRH in amygdala associated with amygdala
9) Confidence 0.30 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701287 Disease Relevance 0.82 Pain Relevance 0.69
METHODS: The effect of LLLT on opioid analgesia and production was evaluated in vivo in a rat model of inflammation as well as in vitro in Jurkat cells, a human T-cell leukemia cell line. mRNA expression of the beta-endorphin precursors proopiomelanocortin and corticotrophin releasing factor was assessed by reverse transcription polymerase chain reaction.
Negative_regulation (assessed) of Transcription (expression) of corticotrophin releasing factor in T-cell
10) Confidence 0.17 Published 2007 Journal Lasers Surg Med Section Body Doc Link 18081143 Disease Relevance 0 Pain Relevance 0
We conclude that the reduction in HPA function reported previously is mediated, at least in part, by a decrease in expression of CRH mRNA and increase in PENK mRNA in the PVN.
Negative_regulation (decrease) of Transcription (expression) of CRH in PVN
11) Confidence 0.17 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679054 Disease Relevance 0.07 Pain Relevance 0
Using in situ hybridization, we found that corticotropin releasing hormone (CRH) mRNA expression in the hypothalamic paraventricular nucleus (PVN) was lower in fetuses from nutrient restricted ewes than in controls.
Negative_regulation (lower) of Transcription (expression) of corticotropin releasing hormone in nucleus
12) Confidence 0.17 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679054 Disease Relevance 0.07 Pain Relevance 0
Using in situ hybridization, we found that corticotropin releasing hormone (CRH) mRNA expression in the hypothalamic paraventricular nucleus (PVN) was lower in fetuses from nutrient restricted ewes than in controls.
Negative_regulation (lower) of Transcription (expression) of CRH in nucleus
13) Confidence 0.17 Published 2001 Journal J. Neuroendocrinol. Section Abstract Doc Link 11679054 Disease Relevance 0.07 Pain Relevance 0
Levels of CRH and neurotensin mRNAs were decreased on the lesioned side in the CEA and oval nucleus of the BST (BSTov) relative to the intact side and to unoperated controls.
Negative_regulation (decreased) of in CEA Transcription (Levels) of CRH in oval nucleus associated with amygdala
14) Confidence 0.15 Published 2002 Journal Brain Res. Section Abstract Doc Link 12126877 Disease Relevance 0 Pain Relevance 0.67

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