INT22339

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Context Info
Confidence 0.67
First Reported 1986
Last Reported 2001
Negated 0
Speculated 2
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 1.36
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Crh) extracellular region (Crh) response to stress (Crh)
cytoplasm (Crh)
Anatomy Link Frequency
median eminence 6
Crh (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Endogenous opioid 2 99.74 Very High Very High Very High
amygdala 1 99.68 Very High Very High Very High
cocaine 10 98.76 Very High Very High Very High
fluoxetine 4 98.28 Very High Very High Very High
dexamethasone 4 95.84 Very High Very High Very High
antagonist 13 94.92 High High
dopamine receptor 4 94.48 High High
anesthesia 2 90.12 High High
corticosteroid 2 86.96 High High
withdrawal 3 86.80 High High
Disease Link Frequency Relevance Heat
Stress 13 99.76 Very High Very High Very High
Weight Loss 1 99.66 Very High Very High Very High
Body Weight 1 99.56 Very High Very High Very High
Appetite Loss 1 99.24 Very High Very High Very High
Urological Neuroanatomy 3 99.20 Very High Very High Very High
Hypothermia 1 84.40 Quite High
Fever 1 82.48 Quite High
Acute-phase Reaction 1 37.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Laparotomy also caused a significant depletion of corticotropin-releasing hormone (CRH-41) in the median eminence (ME).
Positive_regulation (caused) of Negative_regulation (depletion) of corticotropin-releasing hormone in median eminence
1) Confidence 0.67 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.16 Pain Relevance 0.32
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH).
Spec (investigates) Positive_regulation (mediating) of Negative_regulation (effect) of corticotropin-releasing factor associated with endogenous opioid
2) Confidence 0.63 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.34
Laparotomy also caused a significant depletion of corticotropin-releasing hormone (CRH-41) in the median eminence (ME).
Positive_regulation (caused) of Negative_regulation (depletion) of CRH in median eminence
3) Confidence 0.48 Published 2000 Journal Neuroimmunomodulation Section Abstract Doc Link 10810250 Disease Relevance 0.16 Pain Relevance 0.32
Although prednisolone resulted in a marked reduction of basal CRF mRNA, the stress-induced increment of CRF mRNA remained comparable with that found in untreated animals.
Positive_regulation (resulted) of Negative_regulation (reduction) of CRF mRNA associated with stress
4) Confidence 0.47 Published 1990 Journal J. Endocrinol. Section Abstract Doc Link 2280210 Disease Relevance 0.33 Pain Relevance 0.11
The present study investigates the possible role of endogenous opioid peptides in mediating the inhibitory effect of corticotropin-releasing factor (CRF) on circulating luteinizing hormone (LH).
Spec (investigates) Positive_regulation (mediating) of Negative_regulation (effect) of CRF associated with endogenous opioid
5) Confidence 0.45 Published 1986 Journal NIDA Res. Monogr. Section Abstract Doc Link 2893271 Disease Relevance 0 Pain Relevance 0.34
Small decreases (10-13%) in hypothalamic CRH mRNA levels were found again to be induced by 3 days of repeated 'binge' cocaine.
Positive_regulation (induced) of Negative_regulation (decreases) of CRH mRNA associated with cocaine
6) Confidence 0.44 Published 2001 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 11597771 Disease Relevance 0.25 Pain Relevance 0.72
Chronic fluoxetine treatment significantly attenuated the anorexia and body weight loss, as well as the depletion of CRH-41 from the median eminence and the elevation in serum corticosterone levels induced by LPS.
Positive_regulation (induced) of Negative_regulation (depletion) of CRH-41 in median eminence associated with appetite loss, weight loss, body weight and fluoxetine
7) Confidence 0.11 Published 2001 Journal Neuropsychopharmacology Section Abstract Doc Link 11282253 Disease Relevance 0.47 Pain Relevance 0.45

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