INT223416

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 2
Total Number 43
Disease Relevance 64.16
Pain Relevance 34.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Trhde)
Anatomy Link Frequency
neurons 23
IB4 4
peripheral nerve 3
DRG 3
sensory neurons 2
Trhde (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 4326 100.00 Very High Very High Very High
Inflammation 2315 99.86 Very High Very High Very High
Peripheral nerve injury 714 99.82 Very High Very High Very High
Sciatic nerve 546 99.72 Very High Very High Very High
Inflammatory response 378 99.24 Very High Very High Very High
Lasting pain 168 99.24 Very High Very High Very High
Calcitonin gene-related peptide 546 99.04 Very High Very High Very High
Spinal cord 378 97.72 Very High Very High Very High
Pain 294 97.44 Very High Very High Very High
IPN 42 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4326 100.00 Very High Very High Very High
Nervous System Injury 1302 100.00 Very High Very High Very High
INFLAMMATION 2777 99.86 Very High Very High Very High
Nociception 210 99.84 Very High Very High Very High
Cystitis 168 99.80 Very High Very High Very High
Pancreatitis 294 99.52 Very High Very High Very High
Pain 462 99.24 Very High Very High Very High
Stress 126 99.20 Very High Very High Very High
Injury 210 97.96 Very High Very High Very High
Inflammatory Bowel Disease 42 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunostaining showed that the expression of PAP-II was mostly increased in the isolectin B4-positive subset of small DRG neurons after inflammation.
Gene_expression (expression) of PAP-II in DRG associated with dorsal root ganglion and inflammation
1) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2873504 Disease Relevance 1.82 Pain Relevance 0.76
In contrast, PAP-II was absent in Trk-B-immunoreactive DRG neurons (Fig. 4A), suggesting that inflammation-induced expression of PAP-II mainly occurs in small DRG neurons.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion and inflammation
2) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.75 Pain Relevance 1.07
Thus, the expression of PAP-II can be induced in large DRG neurons that express NPY 14 days after peripheral nerve injury.


Gene_expression (expression) of PAP-II in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
3) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.21 Pain Relevance 0.75
The present study shows an inflammation- and nerve injury-triggered expression of PAP-II in rat DRG neurons.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury and inflammation
4) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2873504 Disease Relevance 1.68 Pain Relevance 0.68
Moreover, expression of PAP-II is also increased in gut epithelial cells in human inflammatory bowel disease [28].
Gene_expression (expression) of PAP-II in epithelial cells associated with inflammation
5) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.08 Pain Relevance 0.18
Thus, the expression of PAP-II is induced mainly in IB4-positive subset of small DRG neurons.


Gene_expression (expression) of PAP-II in IB4 associated with dorsal root ganglion
6) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.83 Pain Relevance 1.10
Although the percentage of PAP-II-positive neurons expressing peripherin was slightly decreased (from 54.6 ± 10.3% to 48.7 ± 8.7%), co-expression of PAP-II and peripherin was still present in small DRG neurons (Fig. 7A and 7B).
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion
7) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.35 Pain Relevance 0.84
In the present study, we reveal that the inflammation-induced expression of PAP-II mainly occurs in IB4-positive subset of small DRG neurons but only in some peptidergic small DRG neurons, suggesting that PAP-II may be specifically involved in the inflammatory response of IB4-positve small DRG neurons.
Gene_expression (expression) of PAP-II in IB4 associated with dorsal root ganglion, inflammatory response and inflammation
8) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.85 Pain Relevance 1.09
Peripheral nerve injury-induced expression of PAP-II in DRG neurons
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
9) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.81 Pain Relevance 1.10
Although expression of PAP-I was found in the dorsal root ganglion (DRG) neurons following peripheral nerve injury and cystitis, whether PAP-II could be expressed in DRG neurons in chronic pain models remains unclear.
Gene_expression (expressed) of PAP-II in DRG associated with ganglion cysts, dorsal root ganglion, nervous system injury, lasting pain, cystitis and peripheral nerve injury
10) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2873504 Disease Relevance 1.52 Pain Relevance 0.60
Therefore, we are interested to know whether peripheral nerve injury could induce the expression of PAP-II in DRG neurons.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
11) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.59 Pain Relevance 0.98
Interestingly, the inflammation-induced PAP-II expression in IB4-positive subset of small DRG neurons suggests that this subset of sensory neurons may play an active role in the inflammatory response through a relatively selective mechanism, which might be different from that in peptidergic small DRG neurons.
Gene_expression (expression) of PAP-II in sensory neurons associated with dorsal root ganglion, inflammatory response and inflammation
12) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.61 Pain Relevance 0.91
Therefore, less than 10% of PAP-II-positive neurons contained NPY (Fig. 6A), suggesting that nerve injury-induced expression of PAP-II may represent an early response of DRG neurons to injury.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury and injury
13) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.56 Pain Relevance 0.96
Although the expression of NPY in DRG neurons remained at low levels 2 days after sciatic nerve axotomy, the expression of PAP-II had already been up-regulated in DRG neurons including some large neurons (Fig. 6A).
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion and sciatic nerve
14) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.63 Pain Relevance 1.00
Interestingly, PAP-II expression was shifted from small neurons on day 2 to large DRG neurons that expressed neuropeptide Y during the later post-injury days.
Gene_expression (expression) of PAP-II in DRG associated with dorsal root ganglion, injury and neuropeptide
15) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2873504 Disease Relevance 1.76 Pain Relevance 0.74
Furthermore, the expression of PAP-II was also induced in DRG neurons after peripheral nerve injury.
Gene_expression (expression) of PAP-II in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
16) Confidence 0.48 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2873504 Disease Relevance 1.80 Pain Relevance 0.76
We found that the expression of PAP-II was also induced in DRG neurons after peripheral nerve injury.
Gene_expression (expression) of PAP-II in peripheral nerve associated with dorsal root ganglion, nervous system injury and peripheral nerve injury
17) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.63 Pain Relevance 0.99
The present study shows that peripheral nerve injury induces PAP-II expression in peripherin-containing small DRG neurons which mostly expressed neither CGRP nor IB4, followed by a shift to NPY-containing large DRG neurons 14 days after peripheral axotomy.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury, calcitonin gene-related peptide and peripheral nerve injury
18) Confidence 0.48 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.83 Pain Relevance 0.91
We further identified the subset of small DRG neurons that expressed PAP-II following peripheral inflammation.
Gene_expression (expressed) of PAP-II in neurons associated with dorsal root ganglion and inflammation
19) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.53 Pain Relevance 0.94
Therefore, less than 10% of PAP-II-positive neurons contained NPY (Fig. 6A), suggesting that nerve injury-induced expression of PAP-II may represent an early response of DRG neurons to injury.
Gene_expression (expression) of PAP-II in neurons associated with dorsal root ganglion, nervous system injury and injury
20) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2873504 Disease Relevance 1.65 Pain Relevance 1.01

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox