INT223444

Context Info Confidence 0.28 First Reported 2007 Last Reported 2009 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 2.95 Pain Relevance 0.52

Anatomy Link Frequency CD86 1 dendritic cells 1 skin 1 T cells 1 Mat1a (Mus musculus)

Pain Link Frequency Relevance Heat adenocard 2 96.84 Neuropeptide 3 92.24 addiction 1 89.76 Neurotransmitter 1 81.84 nociceptor 18 74.00 Central nervous system 1 72.12 Pain 5 59.76 Congenital analgesia 1 54.00 substance P 1 37.84 cytokine 18 10.68

Disease Link Frequency Relevance Heat Hypersensitivity 5 100.00 Disease 110 99.40 Infection 129 83.48 Respiratory Disease 9 82.60 Neuroblastoma 3 81.68 Severe Acute Respiratory Syndrome 114 75.00 Increased Venous Pressure Under Development 2 66.20 Hyperhomocysteinemia 5 58.08 Cognitive Disorder 7 55.40 Syndrome 1 54.80

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, there are studies showing a role for AdoMet and AdoHcy in AD [2, 24, 30].

AdoMet Binding (role) of associated with disease

1) Confidence 0.28 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0.13

Inhibitory AMs are believed to prevent the development of immune responses to environmental antigens and allergic responses by interacting with lung dendritic cells and T cells.

AMs Binding (interacting) of in T cells associated with hypersensitivity

2) Confidence 0.20 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2762542 Disease Relevance 0.93 Pain Relevance 0

When cultured in the absence of AMs, aDC upregulated expression of CD86, MHC II and CD40.

AMs Neg (absence) Binding (absence) of in CD86

3) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2762542 Disease Relevance 0.35 Pain Relevance 0

For example, slowly adapting mechanoreceptors [SAMs] that interact with Merkel cells in the skin and whose phenotypic development depends on BDNF/TrkB signaling [3] can only be identified using physiological criteria.

SAMs Binding (interact) of in skin

4) Confidence 0.17 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.11 Pain Relevance 0.39

Inhibitory AMs are believed to prevent the development of immune responses to environmental antigens and allergic responses by interacting with lung dendritic cells and T cells.

AMs Binding (interacting) of in dendritic cells associated with hypersensitivity

5) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Abstract Doc Link PMC2762542 Disease Relevance 0.93 Pain Relevance 0

General Comments

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