INT223447

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.29
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1) plasma membrane (Ntrk1) kinase activity (Ntrk1)
cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 4
nociceptor 4
nerve 2
sympathetic 2
Ntrk1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 154 99.84 Very High Very High Very High
Nerve growth factor 72 99.84 Very High Very High Very High
Trk A 2 92.12 High High
cytokine 2 91.68 High High
dorsal root ganglion 52 88.32 High High
trigeminal ganglion 152 83.76 Quite High
Glutamate receptor 4 56.64 Quite High
Peripheral nervous system 4 46.96 Quite Low
Neuropeptide 28 33.92 Quite Low
sodium channel 8 31.84 Quite Low
Disease Link Frequency Relevance Heat
Death 20 98.96 Very High Very High Very High
Targeted Disruption 124 97.60 Very High Very High Very High
Repression 14 92.48 High High
Ganglion Cysts 354 88.32 High High
Nociception 42 79.36 Quite High
Neurodegenerative Disease 10 59.20 Quite High
Injury 6 30.68 Quite Low
Pain 18 16.08 Low Low
Apoptosis 16 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Runx1 is initially co-expressed with TrkA in the nociceptor lineage [7,8], and initiation of TrkA expression is not dependent on Runx1 [48].
Neg (not) Regulation (dependent) of Gene_expression (expression) of TrkA in nociceptor associated with nociceptor
1) Confidence 0.34 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.20 Pain Relevance 0.30
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Regulation (regulation) of Gene_expression (expression) of Trka
2) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16
Differential analysis of P0 WT versus P0 TrkA mutant mice libraries
Regulation (analysis) of Gene_expression (libraries) of TrkA
3) Confidence 0.27 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0
Brn3a is required for Runx1 expression and the segregation of TrkA/TrkB expression in nociceptor precursors
Regulation (segregation) of Gene_expression (expression) of TrkA in nociceptor associated with nociceptor
4) Confidence 0.25 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.35 Pain Relevance 0.24
In the same study, siRNA knock-down of early Runx1 expression as well as overexpression of a general dominant-negative Runx protein was shown to down-regulate TrkA expression and cause the subsequent death of the neurons.
Regulation (regulate) of Gene_expression (expression) of TrkA in neurons associated with targeted disruption and death
5) Confidence 0.23 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0.61 Pain Relevance 0.17
In sympathetic neurons, ret expression is detected before trkA expression and appears correlated with trkC expression instead.
Regulation (detected) of Gene_expression (expression) of trkA in sympathetic
6) Confidence 0.19 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.34
The acquisition of ret expression in trkA-positive neurons during late embryogenesis requires NGF, apart from its survival action, as shown in NGF/Bax double-mutant mice.
Regulation (acquisition) of Gene_expression (expression) of trkA in neurons associated with nerve growth factor
7) Confidence 0.19 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.32
Survival and differentiation of TrkA-expressing cells are dependent on nerve growth factor (NGF), whereas RET-expressing cells rely instead on members of the GDNF family [38, 39].
Regulation (dependent) of Gene_expression (expressing) of TrkA in nerve associated with nerve growth factor
8) Confidence 0.14 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733376 Disease Relevance 0 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox