INT223448

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Context Info
Confidence 0.60
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.58
Pain Relevance 1.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ret) kinase activity (Ret)
Anatomy Link Frequency
neurons 2
ganglia 1
trunk 1
Ret (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 117 99.24 Very High Very High Very High
Neuropeptide 31 98.68 Very High Very High Very High
noradrenaline 20 94.68 High High
nociceptor 94 94.08 High High
TRP channel 28 85.44 High High
Calcitonin gene-related peptide 88 82.64 Quite High
qutenza 20 82.40 Quite High
trigeminal ganglion 4 68.44 Quite High
Pain 5 50.24 Quite High
Thermal hyperalgesia 4 50.08 Quite High
Disease Link Frequency Relevance Heat
Death 28 97.52 Very High Very High Very High
Ganglion Cysts 266 78.88 Quite High
Pain 9 50.24 Quite High
Hyperalgesia 4 50.08 Quite High
INFLAMMATION 9 47.92 Quite Low
Targeted Disruption 57 47.76 Quite Low
Apoptosis 32 5.00 Very Low Very Low Very Low
Sprains And Strains 24 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 24 5.00 Very Low Very Low Very Low
Nociception 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In situ hybridization for ret mRNA on trunk cross sections from a 13-day-old mouse embryo (E13, a) and a newborn animal (P0, b).
Localization (hybridization) of ret mRNA in trunk
1) Confidence 0.60 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.31 Pain Relevance 0
Only a small early ret-expressing population of DRG neurons is NGF-independent.
Localization (population) of ret-expressing in neurons associated with nerve growth factor
2) Confidence 0.60 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0 Pain Relevance 0.33
In addition, ret mRNA colocalizes in double ISH with mRNA for the neuropeptide vasoactive intestinal peptide (VIP), which in sympathetic ganglia is coexpressed with cholinergic properties (Ernsberger et al. 2000).


Localization (colocalizes) of ret mRNA in ganglia associated with neuropeptide
3) Confidence 0.60 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.05 Pain Relevance 0.34
In ret mutants, no neuron loss is reported from P14 DRG.
Localization (reported) of ret in neuron
4) Confidence 0.52 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.17 Pain Relevance 0.30
At P0, Grik1/GluR5 was largely co-localized with c-ret (data not shown).
Localization (localized) of ret
5) Confidence 0.42 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.05 Pain Relevance 0.26

General Comments

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