INT223459

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.71
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 1.50
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Dock4) cytoplasm (Dock4)
Anatomy Link Frequency
eyes 1
photoreceptor 1
finger 1
Dock4 (Mus musculus)
Pain Link Frequency Relevance Heat
Trk A 1 91.28 High High
nociceptor 18 58.76 Quite High
Glutamate receptor 2 55.80 Quite High
Nerve growth factor 8 48.44 Quite Low
Neuropeptide 3 31.84 Quite Low
sodium channel 1 29.76 Quite Low
anesthesia 14 5.00 Very Low Very Low Very Low
GABAergic 7 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 7 100.00 Very High Very High Very High
Myopia 91 98.68 Very High Very High Very High
Adhesions 7 98.36 Very High Very High Very High
Death 14 97.76 Very High Very High Very High
Ganglion Cysts 16 89.48 High High
Usher Syndrome 7 88.72 High High
Syndrome 8 86.00 High High
Nonsyndromic Deafness 7 85.04 High High
Targeted Disruption 8 84.48 Quite High
Blindness 7 82.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the differential expression of Dock4 (p=0.07) and Myb (p=0.09) just missed significance, and the differential expression of Usp36 and Zmym4 also could not be confirmed.
Gene_expression (expression) of Dock4
1) Confidence 0.71 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.08 Pain Relevance 0
Krt2-6b, Myb, and Dock4 expression
Gene_expression (expression) of Dock4
2) Confidence 0.71 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.33 Pain Relevance 0
Accordingly, eight potentially interesting genes were selected for validation: early growth response 1 (Egr-1), protein kinase B (Akt2), keratin complex 2, basic, gene 6b (Krt2-6b), myeloblastosis oncogene (Myb), FBJ osteosarcoma oncogene (cFos), ubiquitin specific peptidase 36 (Usp36), zinc finger, MYM-type 4 (Zmym4), and dedicator of cytokinesis 4 (Dock4).
Gene_expression (selected) of Dock4 in finger associated with osteogenic sarcomas
3) Confidence 0.62 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.10 Pain Relevance 0
Dock4 is a potent rac activator and an unconventional guanine exchange factor for the Rho family of guanosine triphosphatases (Rho GEF GTPases), as a protein interacting with harmonin, which is expressed in the inner and outer photoreceptor segments.
Gene_expression (expressed) of Dock4 in photoreceptor
4) Confidence 0.62 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0.86 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (levels) of Dock4
5) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
The mRNA expression of Akt2 and Dock4 increased in both diffuser- and ND filter-treated eyes, however, the increase was more pronounced in the diffuser-treated eyes.
Gene_expression (expression) of Dock4 in eyes
6) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
Baseline expression levels of Akt2, Krt2-6b, Myb, Zmym4, Usp36, and Dock4
Gene_expression (expression) of Dock4
7) Confidence 0.55 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2774458 Disease Relevance 0 Pain Relevance 0
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Gene_expression (expression) of Dock4
8) Confidence 0.53 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox