INT223462

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.08
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Hoxb4) nucleus (Hoxb4) DNA binding (Hoxb4)
Anatomy Link Frequency
neurons 1
nociceptors 1
Hoxb4 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 36 99.42 Very High Very High Very High
Pain 10 80.36 Quite High
Spinal cord 6 75.56 Quite High
Inflammatory stimuli 2 43.36 Quite Low
Neuropeptide 6 5.00 Very Low Very Low Very Low
dorsal root ganglion 4 5.00 Very Low Very Low Very Low
Glutamate receptor 4 5.00 Very Low Very Low Very Low
Congenital analgesia 2 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
sodium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 10 80.36 Quite High
INFLAMMATION 2 43.36 Quite Low
Nociception 16 5.00 Very Low Very Low Very Low
Ganglion Cysts 4 5.00 Very Low Very Low Very Low
Hypersensitivity 4 5.00 Very Low Very Low Very Low
Neuroblastoma 2 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Syndrome 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Injury 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus Grik1/GluR5 expression seems to coincide with the appearance of the population of nociceptors that down-regulate TrkA and express c-Ret and bind isolectin B4 [8].
isolectin B4 Binding (bind) of in nociceptors associated with nociceptor
1) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.36
By pharmacological experiments on cultured neonatal rat DRG neurons, Grik1/GluR5 was identified in isolectin B4 binding cells [29] and was shown by double immunhistochemistry to be highly-represented in the P2X3 positive nociceptor population, that are mostly isolectin B4 binding [15].
isolectin B4 Binding (binding) of in neurons associated with nociceptor
2) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.08 Pain Relevance 0.22

General Comments

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