INT223464

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Context Info
Confidence 0.51
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.19
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Crip2) cellular_component (Crip2)
Anatomy Link Frequency
ventral 2
adult mouse 2
Crip2 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 9 99.30 Very High Very High Very High
Trk A 3 92.12 High High
nociceptor 54 59.60 Quite High
Pain 15 59.12 Quite High
Glutamate receptor 6 56.64 Quite High
Neuropeptide 9 31.84 Quite Low
sodium channel 3 29.76 Quite Low
dorsal root ganglion 6 5.00 Very Low Very Low Very Low
Congenital analgesia 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Nociception 24 65.12 Quite High
Targeted Disruption 3 62.92 Quite High
Pain 15 59.12 Quite High
Neuroblastoma 3 36.72 Quite Low
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Hypersensitivity 6 5.00 Very Low Very Low Very Low
Syndrome 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low
Injury 3 5.00 Very Low Very Low Very Low
INFLAMMATION 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When expressed as "fold-change in expression" the SAGE results demonstrate a down regulation of Grik1, Dock4 and Crip2 expression between P0 WT and P0 Trka-/- DRG of about 18, 6 and 3 fold respectively, while QRT-PCR provided an expression ratio between P0 WT and P0 Trka-/- DRG of 17, 4 and 4 fold respectively.


Regulation (regulation) of Gene_expression (expression) of Crip2
1) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.13 Pain Relevance 0.16
On the other hand, it has been shown that the transcription factor RunX3 plays an essential role in the establishment of the proprioceptive neuron phenotype [25] and the targeting of proprioceptive (TrkC-expressing) afferents to the ventral region of the spinal cord [9], raising the possibility that Crip2 expression is under the control of this transcriptional program.
Regulation (under) of Gene_expression (expression) of Crip2 in ventral associated with spinal cord
2) Confidence 0.51 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0 Pain Relevance 0.05
The functional significance of Crip2 expression in DRG neurons remains to be explored, Concerning Grik1/GluR5, our results show unequivocally that, in the adult mouse DRG, this kainate receptor is expressed in the great majority of isolectin B4 binding neurons and is excluded from other neuronal sub-types.
Regulation (significance) of Gene_expression (expression) of Crip2 in adult mouse
3) Confidence 0.38 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.06 Pain Relevance 0.13

General Comments

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