INT223475

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Context Info
Confidence 0.22
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.25
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1, Ntrk2) plasma membrane (Ntrk1, Ntrk2) kinase activity (Ntrk1, Ntrk2)
cytosol (Ntrk2) cytoplasm (Ntrk1)
Anatomy Link Frequency
neurons 1
Ntrk1 (Mus musculus)
Ntrk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 99.80 Very High Very High Very High
Glutamate 6 40.24 Quite Low
nociceptor 18 27.84 Quite Low
dorsal root ganglion 2 11.68 Low Low
agonist 18 5.00 Very Low Very Low Very Low
antidepressant 10 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Eae 5 5.00 Very Low Very Low Very Low
Spinal cord 3 5.00 Very Low Very Low Very Low
Neuropeptide 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 3 89.44 High High
Nociception 8 79.72 Quite High
Neurological Disease 4 79.24 Quite High
Toxicity 1 39.44 Quite Low
Apoptosis 16 35.84 Quite Low
Injury 3 31.52 Quite Low
Neurodegenerative Disease 3 12.96 Low Low
Ganglion Cysts 10 11.68 Low Low
Motor Neuron Diseases 1 6.88 Low Low
Anxiety Disorder 23 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neurotrophins exert their biological functions on neurons through two transmembrane receptors: the p75 neurotrophin receptor (p75NTR) and the Trk receptor tyrosine kinases (NGF binds to TrkA, BDNF and NT-4/5 bind to TrkB, and NT-3 preferentially binds to TrkC) [3], [4].
TrkA Binding (bind) of TrkB in neurons associated with nerve growth factor
1) Confidence 0.22 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2903477 Disease Relevance 0.08 Pain Relevance 0.14
In biochemical studies, it was shown that Dok5 could interact specifically with TrkB and TrkC receptors, but not TrkA, and was involved in neurotrophin induced MAPK activation [20].
TrkA Binding (receptors) of TrkB
2) Confidence 0.16 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.17 Pain Relevance 0

General Comments

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