INT223477

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Context Info
Confidence 0.16
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.30
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Ntrk1, Ntrk3) plasma membrane (Ntrk1, Ntrk3) kinase activity (Ntrk1, Ntrk3)
cytoplasm (Ntrk1, Ntrk3)
Ntrk1 (Mus musculus)
Ntrk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Nerve growth factor 5 99.98 Very High Very High Very High
Central nervous system 6 57.04 Quite High
depression 73 50.00 Quite Low
nociceptor 18 27.48 Quite Low
long-term potentiation 2 27.12 Quite Low
dorsal root ganglion 2 11.32 Low Low
Hippocampus 43 10.64 Low Low
antidepressant 62 5.00 Very Low Very Low Very Low
fluoxetine 18 5.00 Very Low Very Low Very Low
Desipramine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 1 89.44 High High
Congenital Anomalies 9 80.36 Quite High
Nociception 8 79.36 Quite High
Hyperplasia 1 51.52 Quite High
Depression 95 50.00 Quite Low
Mental Disorders 6 35.12 Quite Low
Suicidal Behaviour 123 31.40 Quite Low
Stress 25 20.64 Low Low
Cognitive Disorder 4 14.08 Low Low
Ganglion Cysts 2 11.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In biochemical studies, it was shown that Dok5 could interact specifically with TrkB and TrkC receptors, but not TrkA, and was involved in neurotrophin induced MAPK activation [20].
TrkA Binding (receptors) of TrkC
1) Confidence 0.16 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2241628 Disease Relevance 0.17 Pain Relevance 0
The interaction of neurotrophins with the Trk receptors is specific: NGF binds with TrkA, BDNF and NT 4 both bind with TrkB, and NT 3 binds with the highest affinity to TrkC but is also capable of signaling through TrkA and TrkB.
TrkA Binding (binds) of TrkC associated with nerve growth factor
2) Confidence 0.01 Published 2009 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2732010 Disease Relevance 0.13 Pain Relevance 0.19

General Comments

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