INT22353

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Context Info
Confidence 0.17
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.98
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cps1) protein complex (Cps1) ligase activity (Cps1)
cytoplasm (Cps1)
Anatomy Link Frequency
neurons 1
APT 1
Cps1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 100.00 Very High Very High Very High
Glutamate 4 98.64 Very High Very High Very High
orphanin 5 97.40 Very High Very High Very High
tolerance 3 93.84 High High
Opioid 2 91.88 High High
Spinal cord 2 76.00 Quite High
central pain 2 75.00 Quite High
Inflammation 3 59.52 Quite High
Multiple sclerosis 1 47.52 Quite Low
Pain 3 25.00 Low Low
Disease Link Frequency Relevance Heat
Complex Regional Pain Syndromes 10 100.00 Very High Very High Very High
Cryptococcus Infection 1 93.52 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 90.28 High High
INFLAMMATION 4 75.00 Quite High
Sepsis 1 64.72 Quite High
Demyelinating Disease 1 47.52 Quite Low
Stroke 1 46.56 Quite Low
Frailty 1 46.24 Quite Low
Exsanguination 2 5.00 Very Low Very Low Very Low
Insulin Resistance 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these findings suggest that APT regulates ZI inputs to PO and that enhanced APT activity during CPS contributes to the abnormally high activity of PO neurons in CPS.
Positive_regulation (activity) of CPS in APT associated with complex regional pain syndromes
1) Confidence 0.17 Published 2010 Journal J. Neurophysiol. Section Abstract Doc Link 20357063 Disease Relevance 0.59 Pain Relevance 0.11
Eighty-two neurons located in the T7-T9 segments were tested for responses to electrical stimulation of CPS fibers.
Positive_regulation (stimulation) of CPS in neurons
2) Confidence 0.10 Published 1990 Journal Brain Res. Section Abstract Doc Link 2282489 Disease Relevance 0 Pain Relevance 0
Moreover, both CPS and CPT inhibit NF-kappaB activation in response to different agents including TNF-alpha.
Positive_regulation (activation) of CPS associated with qutenza
3) Confidence 0.07 Published 2002 Journal Eur. J. Immunol. Section Abstract Doc Link 12115659 Disease Relevance 0.20 Pain Relevance 0.49
Because the activation of CPS and RVLM by microinjections of L-glutamate results in pressor and tachycardic responses, inhibition of these areas by nociceptin and endomorphin-2 elicits depressor and bradycardic responses.
Positive_regulation (activation) of CPS associated with glutamate and orphanin
4) Confidence 0.02 Published 2002 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 11906492 Disease Relevance 0 Pain Relevance 0.46
A linear stimulation constant (Model D) was sufficient to describe the biosignal mediated increase in OTC, alanine aminotransferase(ALT) and carbamoyl phosphate synthetase (CPS).
Positive_regulation (increase) of CPS
5) Confidence 0.01 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733100 Disease Relevance 0 Pain Relevance 0.08
METHODS: All HIV-infected patients with a CD4+ count <200 cells/mm3 attending 1 of 2 Phnom Penh hospitals for the first time were systematically screened for serum CPS.
Positive_regulation (screened) of serum CPS
6) Confidence 0.01 Published 2007 Journal J. Acquir. Immune Defic. Syndr. Section Body Doc Link 17577124 Disease Relevance 0.18 Pain Relevance 0

General Comments

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