INT223534

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Context Info
Confidence 0.67
First Reported 2007
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.29
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (ERVW-1)
Anatomy Link Frequency
brain 2
ERVW-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 3 99.32 Very High Very High Very High
addiction 51 50.00 Quite Low
anesthesia 11 5.00 Very Low Very Low Very Low
Central nervous system 7 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
rheumatoid arthritis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 4 99.32 Very High Very High Very High
Sprains And Strains 43 96.92 Very High Very High Very High
Infection 114 94.44 High High
Burns 91 86.00 High High
Dementia 6 80.44 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 72 79.64 Quite High
Viral Meningitis 7 79.32 Quite High
Viral Infection 3 76.56 Quite High
Giant Cell Tumors 1 66.60 Quite High
Cancer 2 58.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another group of putative MuERVs, defective in their genome structures, had intact coding potentials for gag, pol, and/or env polypeptides and it is likely that changes in the expression of these individual proteins affect the host cells' normal physiology, such as overexpression of syncytin in the brain of multiple sclerosis patients.
Positive_regulation (overexpression) of Gene_expression (overexpression) of syncytin in brain associated with multiple sclerosis
1) Confidence 0.67 Published 2007 Journal BMC Genomics Section Body Doc Link PMC2241634 Disease Relevance 0.43 Pain Relevance 0.05
Because LV vector-mediated gene expression is rapid, and tropism can be manipulated by changing the envelope protein expressed in the cell line used for viral packaging [12], we believe that it can be effectively utilized to identify functional, cell-specific promoters in diverse experimental paradigms.
Positive_regulation (changing) of Gene_expression (expressed) of envelope protein
2) Confidence 0.45 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2765473 Disease Relevance 0.08 Pain Relevance 0
Similar to the parent Env, these chimeras were functional in cell-to-cell fusion assays but did not efficiently mediate production of Env-pseudotyped viruses.
Neg (not) Positive_regulation (mediate) of Gene_expression (production) of Env-pseudotyped
3) Confidence 0.41 Published 2008 Journal Retrovirology Section Body Doc Link PMC2576352 Disease Relevance 0.59 Pain Relevance 0
The expression of the SIV envelope glycoprotein by SIVmac239?
Positive_regulation (by) of Gene_expression (expression) of envelope glycoprotein
4) Confidence 0.11 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2621341 Disease Relevance 0.19 Pain Relevance 0

General Comments

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