INT22354

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Context Info
Confidence 0.63
First Reported 1990
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 2.15
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Lhb) molecular_function (Lhb) cellular_component (Lhb)
biological_process (Lhb)
Anatomy Link Frequency
neurons 4
habenula 2
eye 1
DA neurons 1
tail 1
Lhb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 5 99.48 Very High Very High Very High
depression 40 99.44 Very High Very High Very High
midbrain 112 97.80 Very High Very High Very High
antidepressant 24 97.68 Very High Very High Very High
wide dynamic range 4 97.48 Very High Very High Very High
Morphine 8 96.88 Very High Very High Very High
spinal dorsal horn 3 95.72 Very High Very High Very High
analgesia 8 95.00 High High
Pain threshold 2 95.00 High High
GABAergic 40 94.36 High High
Disease Link Frequency Relevance Heat
Shock 9 99.98 Very High Very High Very High
Nociception 16 99.52 Very High Very High Very High
Depression 56 99.44 Very High Very High Very High
Stress 32 99.36 Very High Very High Very High
Schizophrenia 56 95.32 Very High Very High Very High
Pain 16 95.00 High High
Anxiety Disorder 32 94.72 High High
Psychosis 16 90.96 High High
Rotator Cuff Tears 49 87.84 High High
Tendinopathy 2 69.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that the activation of MHb increased TFL, whereas activation of LHb decreased TFL.
Positive_regulation (activation) of LHb in MHb
1) Confidence 0.63 Published 1995 Journal Sheng Li Xue Bao Section Abstract Doc Link 7570117 Disease Relevance 0.25 Pain Relevance 0.29
In three animal models of depression, metabolic activity in the LHb is specifically increased (Caldecott-Hazard et al. 1988) and administration of the antidepressant drug tranylcypromine inhibits the elevation of metabolic rate in the LHb as well as the depressive behaviours.
Positive_regulation (increased) of LHb associated with antidepressant and depression
2) Confidence 0.58 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.57 Pain Relevance 0.36
In monkeys performing a visually guided saccade task, LHb neurons are activated by visual targets that signify the absence of a reward and inhibited by targets that predict forthcoming reward (whereas DA neurons of the SNc show the opposite responsiveness).
Positive_regulation (activated) of LHb in DA neurons
3) Confidence 0.58 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.34
Electrical stimulation of the LHb inhibits the activity of DA neurons in the VTA and SNc (Christoph et al. 1986), probably as a result of excitatory LHb efferents activating GABAergic interneurons in the ventral midbrain, which in turn inhibit DA cells (Ji & Shepard 2007).
Positive_regulation (stimulation) of LHb in interneurons associated with gabaergic and midbrain
4) Confidence 0.58 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.39
In unrewarded trials, the activation of LHb neurons preceded the inhibition of SNc neurons and mild electrical stimulation of the LHb inhibits the SNc.
Positive_regulation (stimulation) of LHb in neurons
5) Confidence 0.58 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.25
In unrewarded trials, the activation of LHb neurons preceded the inhibition of SNc neurons and mild electrical stimulation of the LHb inhibits the SNc.
Positive_regulation (activation) of LHb in neurons
6) Confidence 0.58 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0 Pain Relevance 0.30
Ipsilateral stimulation of the LHb produced a significant attenuation of nociceptive response of wide dynamic range (WDR) neurons in the rat spinal dorsal horn.
Positive_regulation (stimulation) of LHb in neurons associated with nociception, spinal dorsal horn and wide dynamic range
7) Confidence 0.47 Published 1994 Journal Sheng Li Xue Bao Section Abstract Doc Link 7973822 Disease Relevance 0.17 Pain Relevance 0.32
The fact that stimulation of LHb facilitated tail-flick reflex appears to be quite well explained by its enhancement effect on the tail-flick related response of both the on- and the off-cells.
Positive_regulation (stimulation) of LHb in tail associated with tail-flick
8) Confidence 0.47 Published 1996 Journal Sheng Li Xue Bao Section Abstract Doc Link 9389194 Disease Relevance 0 Pain Relevance 0.26
Single shock stimulation of the lateral habenula (LHb) inhibited 89% of the tested DAergic neurons, most of which (83.8%) were also inhibited by PNS.
Positive_regulation (stimulation) of LHb in habenula associated with shock
9) Confidence 0.47 Published 1990 Journal Brain Res. Section Abstract Doc Link 2282499 Disease Relevance 0.26 Pain Relevance 0.04
The LHb is responsive to various noxious stimuli in the rat (Benabid & Jeaugey 1989) and the activation of LHb neurons by nociceptive inputs may be responsible for the inhibition of DA neurons of the SNc (Gao et al. 1996).
Positive_regulation (activation) of LHb in neurons associated with nociception
10) Confidence 0.39 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.25 Pain Relevance 0.39
In addition, induction of Fos immunoreactivity, which is indicative of neuronal activation, occurs in the LHb in response to stress (Smith et al. 1997) and both electrical stimulation or morphine injections into the habenula produces analgesia in a rat model of tonic pain (Cohen & Melzack 1985, 1986).
Positive_regulation (occurs) of LHb in habenula associated with stress, pain, analgesia and morphine
11) Confidence 0.39 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.29 Pain Relevance 0.44
The habenula shows a significant increase in glucose usage during rapid eye movement (REM) sleep in cats (Lydic et al. 1991) and electrical stimulation of the LHb causes a decrease in REM sleep and an increase in non-REM sleep (Goldstein 1983).
Positive_regulation (stimulation) of LHb in eye
12) Confidence 0.39 Published 2008 Journal Philosophical Transactions of the Royal Society B: Biological Sciences Section Body Doc Link PMC2666075 Disease Relevance 0.14 Pain Relevance 0.36
The purpose of this study was to evaluate whether VEGF and angiogenesis can be observed in the degeneration of the LHB.
Positive_regulation (degeneration) of LHB
13) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936349 Disease Relevance 0.22 Pain Relevance 0

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