INT223579

Context Info Confidence 0.18 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0

cytosol (PTEN, PIK3CG) plasma membrane (PTEN, PIK3CG) cytoplasm (PTEN, PIK3CG) lipid binding (PTEN) cell proliferation (PTEN) nucleus (PTEN)

PTEN (Homo sapiens) PIK3CG (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 1 5.00 nud 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 30 99.12 Cancer 26 66.88 Disease Progression 1 65.16 Disease 17 63.88 Apoptosis 1 43.60 Advanced Or Metastatic Breast Cancer 11 5.00 Vomiting 5 5.00 Diarrhoea 3 5.00 Endometriosis (extended) 3 5.00 Immunotherapy Of Cancer 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

A further 15% to 35% of breast cancer patients demonstrate reduced expression of PTEN (phosphatase and tensin homolog deleted on chromosome ten), an endogenous inhibitor of the PI3K/Akt pathway [47].

PTEN Negative_regulation (inhibitor) of PI3K associated with breast cancer

1) Confidence 0.18 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.56 Pain Relevance 0

General Comments

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