INT223582

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.67
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MTOR, ESR1) signal transduction (MTOR, ESR1) nucleus (MTOR, ESR1)
nucleoplasm (ESR1) mitochondrion (MTOR) Golgi apparatus (MTOR)
MTOR (Homo sapiens)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 1 36.96 Quite Low
addiction 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Cancer 30 99.96 Very High Very High Very High
Cancer 26 85.60 High High
Hyperglycemia 2 79.60 Quite High
Mucositis 1 59.72 Quite High
Diarrhoea 3 58.92 Quite High
Toxicity 2 46.96 Quite Low
Hypertension 1 39.12 Quite Low
Headache 1 36.96 Quite Low
Proteinuria 1 34.88 Quite Low
Apoptosis 1 22.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the setting of hormone receptor positive breast cancer, mTOR inhibition and the resulting increase in Akt signaling could result in ER phosphorylation on Ser167 and negate the effects of aromatase inhibition, thus limiting the therapeutic benefit of this combination.


Negative_regulation (inhibition) of mTOR Positive_regulation (result) of Phosphorylation (phosphorylation) of ER associated with breast cancer
1) Confidence 0.31 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.67 Pain Relevance 0

General Comments

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