INT223583

Context Info Confidence 0.07 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.18 Pain Relevance 0

plasma membrane (TXK, ERBB2) nucleus (TXK, ERBB2) cytoplasm (TXK, ERBB2) cell proliferation (ERBB2) signal transduction (ERBB2) DNA binding (TXK)

TXK (Homo sapiens) ERBB2 (Homo sapiens)

Pain Link Frequency Relevance Heat addiction 1 5.00 nud 1 5.00 headache 1 5.00

Disease Link Frequency Relevance Heat Cancer 26 94.80 Advanced Or Metastatic Breast Cancer 11 85.92 Breast Cancer 30 41.60 Metastasis 1 25.04 Diarrhoea 3 17.28 Vomiting 5 16.48 Exanthema 1 15.84 Fatigue 1 15.12 Disease 17 15.04 Endometriosis (extended) 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Lapatinib is an oral tyrosine kinase inhibitor of both EGFR and HER2.

tyrosine kinase Negative_regulation (inhibitor) of HER2

1) Confidence 0.07 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.18 Pain Relevance 0

General Comments

This test has worked.