INT223599

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Context Info
Confidence 0.42
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.52
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (MTOR) Golgi apparatus (MTOR) endoplasmic reticulum (MTOR)
cytoplasm (MTOR) cytosol (MTOR) signal transduction (MTOR)
Anatomy Link Frequency
plasma 1
blood 1
platelet 1
MTOR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 34 97.00 Very High Very High Very High
cytokine 15 94.08 High High
antagonist 15 87.68 High High
Inflammation 28 85.40 High High
rheumatoid arthritis 1 69.12 Quite High
Bile 1 64.84 Quite High
addiction 1 64.20 Quite High
headache 7 28.32 Quite Low
Catecholamine 16 12.52 Low Low
imagery 76 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Renal Cancer 108 99.84 Very High Very High Very High
Obstructive Sleep Apnea 292 99.40 Very High Very High Very High
Nicotine Addiction 21 97.92 Very High Very High Very High
Shock 3 97.64 Very High Very High Very High
Stomach Cancer 2 97.52 Very High Very High Very High
Obesity 33 97.36 Very High Very High Very High
Advanced Or Metastatic Breast Cancer 129 97.04 Very High Very High Very High
Fatigue 25 95.04 Very High Very High Very High
Metastasis 112 95.00 High High
Pressure And Volume Under Development 23 94.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-untranslated regions and encoding proteins involved in G1- to S-phase progression.30 Mitogen-induced activation of the S6K1 is dependent on mTOR function and has been implicated in the translational regulation of mRNAs possessing a 5?
Regulation (dependent) of mTOR
1) Confidence 0.42 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004583 Disease Relevance 0.15 Pain Relevance 0
Besides inhibition of VEGF signaling, the mammalian target of rapamycin (mTOR) is another important therapeutic target in RCC, although its mechanisms of activation are not yet fully understood. mTOR may play a role in the development of RCC and is associated with elevated HIF activity [14]. mTOR inhibitors seem to down-regulate HIF activity primarily when the mTOR pathway is abnormally activated [15, 16].
Regulation (target) of mammalian target of rapamycin associated with renal cancer
2) Confidence 0.26 Published 2010 Journal Target Oncol Section Body Doc Link PMC2929340 Disease Relevance 0.35 Pain Relevance 0.09
B; Jd-1 = inhibitor of differentiation and DNA binding-1; MAPK = mitogen-activated protein kinase; MDR = multidrug resistance; mTOR = mammalian target of rapamycin; NF-?
Regulation (target) of mTOR
3) Confidence 0.21 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 0.89 Pain Relevance 0
AI = aromatase inhibitor; CR = clinical benefit rate; EGFR = epidermal growth factor receptor; ER = estrogen receptor; FTI = farnesyltransferase inhibitor; HDAC = histone deacetylation; HER = human epidermal receptor; MAPK = mitogenic-activated protein kinase; mTOR = mammalian target of rapamycin; PDGFR = platelet-derived growth factor receptor; PFS = progression free survival; PgR = progesterone receptor; PI3K = phosphatidylinositol 3-kinase; PR = partial response; RR = response rate; SAHA = suberoylanilide hydroxamic acid; SD = stable disease; VEGF = vascular endothelial growth factor.


Regulation (target) of mTOR in platelet associated with disease
4) Confidence 0.20 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.31 Pain Relevance 0.03
This includes an increase of eNOS activity via heat-shock protein 90 (HSP 90), which increases nitric oxide production, protein synthesis and cell proliferation via mammalian target of rapamycin (mTOR) pathway and activation of S6K.
Regulation (target) of mTOR associated with shock
5) Confidence 0.20 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686255 Disease Relevance 0.79 Pain Relevance 0.19
In contrast, the dynamin inhibitor dynasore had no effect on FRAP under unstimulated conditions but reduced the level of recovery following agonist stimulation.
Neg (no) Regulation (effect) of FRAP associated with agonist
6) Confidence 0.18 Published 2010 Journal Journal of Neurochemistry Section Abstract Doc Link PMC2878604 Disease Relevance 0 Pain Relevance 0.05
The protein mammalian target of rapamycin (mTOR) is activated downstream by phosphorylated Akt.
Regulation (target) of mTOR
7) Confidence 0.14 Published 2008 Journal Breast Cancer Res Section Body Doc Link PMC2575526 Disease Relevance 1.24 Pain Relevance 0
In vitro effect of H2O2 on FRAP
Regulation (effect) of FRAP
8) Confidence 0.14 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0 Pain Relevance 0
Temsirolimus is a highly specific inhibitor of the mammalian target of rapamycin (mTOR), a large polypeptide kinase which forms part of the PI3K/Akt pathway.
Regulation (target) of mTOR
9) Confidence 0.13 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2527326 Disease Relevance 1.15 Pain Relevance 0
RAD001 is a highly specific inhibitor of the mammalian target of rapamycin (mTOR), a large polypeptide kinase which forms part of the PI3K/Akt pathway.
Regulation (target) of mTOR
10) Confidence 0.12 Published 2008 Journal J Hematol Oncol Section Body Doc Link PMC2579406 Disease Relevance 0.56 Pain Relevance 0
mammalian target of rapamycin (mTOR) pathway downstream of CXCR4 was shown to
Regulation (target) of mTOR
11) Confidence 0.10 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.60 Pain Relevance 0.14
Therefore, correction of plasma volume changes in FRAP and H2O2 activities in the morning data was unnecessary.


Regulation (changes) of FRAP in plasma
12) Confidence 0.10 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0.22 Pain Relevance 0
Moreover, no significant alterations of evening vs. morning LBCL, blood H2O2 activities and FRAP were noted in OSAS patients.
Neg (no) Regulation (alterations) of FRAP in blood associated with obstructive sleep apnea
13) Confidence 0.10 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 1.04 Pain Relevance 0
GE carried out the in vitro experiment verifying the effect of H2O2 on FRAP.
Regulation (effect) of FRAP
14) Confidence 0.08 Published 2008 Journal J Negat Results Biomed Section Body Doc Link PMC2607253 Disease Relevance 0.23 Pain Relevance 0

General Comments

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