INT223616

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Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (PDGFRB) cytoplasmic membrane-bounded vesicle (PDGFRB) plasma membrane (PDGFRB)
nucleus (PDGFRB) cytoplasm (PDGFRB) signal transducer activity (PDGFRB)
PDGFRB (Homo sapiens)
Pain Link Frequency Relevance Heat
nud 1 95.44 Very High Very High Very High
Pain 8 41.88 Quite Low
Analgesic 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
fibrosis 1 5.00 Very Low Very Low Very Low
addiction 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
positron emission tomography 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dyspepsia 1 95.44 Very High Very High Very High
Vomiting 5 94.88 High High
Cancer 99 94.80 High High
Prostate Cancer 53 90.20 High High
Breast Cancer 30 87.40 High High
Adhesions 1 82.56 Quite High
Chronic Myeloid Leukemia 1 80.64 Quite High
Metastasis 38 79.32 Quite High
Disease 75 60.36 Quite High
Chordoma 30 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A trial is recruiting patients with PDGFR or c-kit over-expression to letrozole plus imatinib and will include a parallel biomarker analysis.


PDGFR Binding (recruiting) of
1) Confidence 0.32 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2242654 Disease Relevance 0.58 Pain Relevance 0.05
It can be activated upon engagement of growth factor receptors, such as EGFR, PDGFR, INSR or IGF1R, and in turn activate downstream PLC and PI3K signaling pathways [51], [52], [66].
PDGFR Binding (engagement) of
2) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 1.37 Pain Relevance 0
, together with PDGFR-?
PDGFR Binding (with) of
3) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2828414 Disease Relevance 0.38 Pain Relevance 0

General Comments

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