INT223641

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm1) nucleus (Grm1) signal transducer activity (Grm1)
Anatomy Link Frequency
brain 3
hypothalamus 1
Grm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 60 100.00 Very High Very High Very High
Glutamate receptor 22 100.00 Very High Very High Very High
nMDA receptor 20 100.00 Very High Very High Very High
ischemia 2 97.64 Very High Very High Very High
Nucleus accumbens 26 94.44 High High
Hippocampus 14 93.44 High High
5HT 8 78.20 Quite High
antagonist 10 74.88 Quite High
Serotonin 16 70.72 Quite High
Dopamine 14 66.08 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 97.64 Very High Very High Very High
Injury 54 96.32 Very High Very High Very High
Brain Injury 150 85.12 High High
Schizophrenia 10 55.12 Quite High
Disease 6 51.16 Quite High
Death 4 48.64 Quite Low
Stroke 2 30.72 Quite Low
Amnesia 4 14.72 Low Low
Cognitive Disorder 10 13.60 Low Low
Depression 2 12.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Transcription (levels) of mGluR1 in brain associated with ischemia
1) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.64 Pain Relevance 0.08
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Neg (unchanged) Transcription (level) of mGluR1 in brain associated with ischemia
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.65 Pain Relevance 0.08
In the hypothalamus, the mRNA levels of GluR1, GluR3, mGluR1, mGluR3 and NR1 were significantly increased also after the administration of the highest MDMA dose, Figure 2C.
Transcription (levels) of mGluR1 in hypothalamus
3) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of mGluR1 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
4) Confidence 0.41 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.68

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox