INT223645

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Context Info
Confidence 0.25
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.16
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Grm7) plasma membrane (Grm7) neurological system process (Grm7)
protein complex (Grm7) signal transducer activity (Grm7)
Anatomy Link Frequency
neurons 2
Grm7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate receptor 10 100.00 Very High Very High Very High
Hippocampus 4 88.04 High High
ischemia 2 68.88 Quite High
cerebral cortex 4 66.88 Quite High
agonist 2 50.96 Quite High
antagonist 4 50.44 Quite High
Glutamate 8 50.00 Quite Low
nMDA receptor 2 40.72 Quite Low
GABAergic 1 30.72 Quite Low
gABA 7 26.76 Quite Low
Disease Link Frequency Relevance Heat
Manic Depressive Disorder 125 94.44 High High
Injury 27 86.32 High High
Brain Injury 75 80.48 Quite High
Cv Unclassified Under Development 2 68.88 Quite High
Intellectual Impairment 1 61.52 Quite High
Neurodegenerative Disease 4 55.40 Quite High
Stroke 1 43.32 Quite Low
Disease 9 28.04 Quite Low
Pressure Volume 2 Under Development 11 6.00 Low Low
Hypoxia 3 5.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, the study by Zhou and colleagues also showed that in primary culture of hippocampal neurons treated with lithium or VPA, levels of the protein glutamate receptor metabotropic 7 (GRM7), one of the miR-34a targets, was increased thus showing that miR-34a might contribute to mediating the effect of lithium and VPA on GRM7 [158].


Positive_regulation (increased) of Gene_expression (levels) of protein glutamate receptor metabotropic 7 in neurons associated with glutamate receptor
1) Confidence 0.25 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.47 Pain Relevance 0.09
However, the expression of group II mGluR decreased when the expression of group I and III mGluRs increased in our study.
Positive_regulation (increased) of Gene_expression (expression) of mGluRs
2) Confidence 0.01 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.69 Pain Relevance 0.12

General Comments

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