INT223653

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Context Info
Confidence 0.69
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.40
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Grm5) cytoplasm (Grm5) signal transducer activity (Grm5)
Anatomy Link Frequency
brain 3
Grm5 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 39 100.00 Very High Very High Very High
Glutamate receptor 25 100.00 Very High Very High Very High
nMDA receptor 11 100.00 Very High Very High Very High
ischemia 2 97.64 Very High Very High Very High
Nucleus accumbens 13 95.40 Very High Very High Very High
Hippocampus 7 94.40 High High
5HT 4 78.20 Quite High
antagonist 11 74.88 Quite High
Serotonin 8 70.72 Quite High
Dopamine 7 66.08 Quite High
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 2 97.64 Very High Very High Very High
Injury 54 96.32 Very High Very High Very High
Brain Injury 150 85.12 High High
Schizophrenia 5 55.12 Quite High
Disease 6 51.16 Quite High
Death 3 48.64 Quite Low
Stroke 2 30.72 Quite Low
Amnesia 2 14.72 Low Low
Cognitive Disorder 5 13.60 Low Low
Depression 1 12.84 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Transcription (levels) of mGluR5 in brain associated with ischemia
1) Confidence 0.69 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.65 Pain Relevance 0.08
Iversen's study even observed a decreased mRNA levels for mGluR1, mGluR2, mGluR5 and an unchanged mRNA level for mGluR3 in regions of rat brain after transient global ischemia [39].
Neg (unchanged) Transcription (level) of mGluR5 in brain associated with ischemia
2) Confidence 0.67 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC2242800 Disease Relevance 0.64 Pain Relevance 0.08
The binding pocket was similar for all ligands docked to all receptors, and is exemplary described in more detail for mGluR5, below.
Transcription (described) of mGluR5
3) Confidence 0.67 Published 2008 Journal BMC Bioinformatics Section Body Doc Link PMC2259417 Disease Relevance 0 Pain Relevance 0
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of mGluR5 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
4) Confidence 0.36 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.68

General Comments

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