INT223678

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Context Info
Confidence 0.75
First Reported 2008
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 3
Total Number 9
Disease Relevance 1.11
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK4) extracellular region (KLK4)
Anatomy Link Frequency
appendages 1
KLK4 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 21 80.40 Quite High
sodium channel 7 70.52 Quite High
Piles 28 50.64 Quite High
Pain 14 42.92 Quite Low
Inflammation 7 35.40 Quite Low
Sciatic nerve 7 30.48 Quite Low
dexamethasone 7 28.20 Quite Low
conotoxin 14 5.00 Very Low Very Low Very Low
Ziconotide 14 5.00 Very Low Very Low Very Low
Spinal cord 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 86 98.80 Very High Very High Very High
Sprains And Strains 209 97.32 Very High Very High Very High
Targeted Disruption 4 86.32 High High
Tension-type Headache 14 80.40 Quite High
Poisoning 14 67.84 Quite High
Shellfish Poisoning 77 60.80 Quite High
Anorectal Disorders 28 50.64 Quite High
Pseudomonas Infection 34 50.00 Quite Low
Arthralgia 7 42.92 Quite Low
Pain 14 42.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We therefore hypothesized that hxc might also play a role in the outer surface expression of PstS PA5369 and performed immunoblot analysis of sheared appendages in strains P. aeruginosa PAO1 and its derivative mutant ?
Gene_expression (expression) of PstS in appendages associated with sprains and strains
1) Confidence 0.75 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242829 Disease Relevance 0.17 Pain Relevance 0
The outer surface expression of PstS PA5369 observed in the current study is at variance with its previously reported characterization as a periplasmic protein.
Gene_expression (expression) of PstS
2) Confidence 0.75 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2242829 Disease Relevance 0.09 Pain Relevance 0
In freshwater environments the PSTs are produced by prokaryotic cyanobacteria belonging to the genera Anabaena, Cylindrospermopsis, Aphanizomenon, Planktothrix and Lyngbya.
Gene_expression (produced) of PSTs
3) Confidence 0.21 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.32 Pain Relevance 0
The genetic characterization of PST biosynthesis pathways from diverse producer organisms has increased our insight into sxt tailoring reactions and the molecular understanding of the mechanisms by which a particular suite of PSTs can be synthesized.
Gene_expression (synthesized) of PSTs
4) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.13 Pain Relevance 0.11
In marine environments, PSTs are primarily produced by the eukaryotic dinoflagellates, belonging to the genera Alexandrium, Gymnodinium and Pyrodinium [8–10].
Gene_expression (produced) of PSTs
5) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.10 Pain Relevance 0
The PSTs are primarily produced in detrimental concentrations during harmful algal bloom (HAB) events [2–5] Over the last few decades, HABs have become more frequent, intense, and span a wider global distribution, the cause of which is still under debate [3,6].
Gene_expression (produced) of PSTs
6) Confidence 0.18 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.06 Pain Relevance 0
Similarly, the recently identified M-toxins (M1-5) are reportedly bivalve metabolites of the PSTs and are not present in PST- producing microalgae [56].
Neg (not) Gene_expression (present) of PSTs
7) Confidence 0.16 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0 Pain Relevance 0
Since PSTs are produced by distantly related organisms, spanning two domains, including cyanobacteria, dinoflagellates and the Panamanian golden frog, it is possible that their occurrence in nature is more widespread than we know.
Gene_expression (produced) of PSTs
8) Confidence 0.14 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0 Pain Relevance 0.04
In some cases, these biotransformations can result in new PSTs that cannot be biosynthesized by cyanobacteria or dinoflagellates alone (Figure 2).
Neg (cannot) Gene_expression (biosynthesized) of PSTs
9) Confidence 0.14 Published 2010 Journal Marine Drugs Section Body Doc Link PMC2920551 Disease Relevance 0.24 Pain Relevance 0

General Comments

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