INT22369

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Context Info
Confidence 0.47
First Reported 1990
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 6.13
Pain Relevance 6.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Drd1a) endoplasmic reticulum (Drd1a) plasma membrane (Drd1a)
nucleus (Drd1a) intracellular (Drd1a) signal transducer activity (Drd1a)
Anatomy Link Frequency
substantia nigra 1
neurons 1
striatum 1
Drd1a (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 1190 100.00 Very High Very High Very High
dopamine receptor 14 100.00 Very High Very High Very High
antagonist 94 99.96 Very High Very High Very High
Endogenous opioid 4 99.42 Very High Very High Very High
monoamine 34 99.08 Very High Very High Very High
Morphine 10 98.94 Very High Very High Very High
Serotonin 155 98.16 Very High Very High Very High
Eae 16 97.68 Very High Very High Very High
halothane 7 97.56 Very High Very High Very High
narcan 7 97.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Attention Deficit Hyperactivity Disorder 979 99.68 Very High Very High Very High
Targeted Disruption 50 98.32 Very High Very High Very High
Injury 2 98.24 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 66 95.52 Very High Very High Very High
Cognitive Disorder 57 95.40 Very High Very High Very High
Parkinson's Disease 2 95.28 Very High Very High Very High
Disease 76 81.28 Quite High
Myelodysplastic Syndromes 4 73.24 Quite High
Mental Disorders 6 70.24 Quite High
Basal Ganglia Disease 2 64.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Simple compensatory up-regulation of D5 DA receptors in response to D1 receptor subtype loss does not explain our findings, because genetic inactivation of the D1 DA receptor does not alter levels of D5 DA receptor expression.
Negative_regulation (loss) of D1 receptor associated with dopamine
1) Confidence 0.47 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 12111832 Disease Relevance 0.86 Pain Relevance 0.55
The MAC-reducing effect of L-DOPA was attenuated by selective antagonism of the D2 dopamine receptor with YM-09151-2 while selective blockade of the D1 dopamine receptor with SCH-23390 did not alter L-DOPA's effect on the MAC for halothane. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) decreased striatal dopamine by 82% and increased the MAC for halothane by 27%.
Negative_regulation (blockade) of D1 dopamine receptor associated with parkinson's disease, dopamine, dopamine receptor and halothane
2) Confidence 0.36 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2282937 Disease Relevance 0.18 Pain Relevance 0.64
Striatal mRNA levels for PPE, PDyn, and DRD1 and DRD2 receptors revealed a significant change in the expression of markers present in medium spiny neurons projecting to the substantia nigra (direct pathway).
Negative_regulation (receptors) of DRD1 in substantia nigra associated with substantia nigra
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736587 Disease Relevance 0 Pain Relevance 0.37
Simple compensatory up-regulation of D5 DA receptors in response to D1 receptor subtype loss does not explain our findings, because genetic inactivation of the D1 DA receptor does not alter levels of D5 DA receptor expression.
Negative_regulation (inactivation) of D1 DA receptor associated with dopamine
4) Confidence 0.35 Published 2002 Journal J. Neurosci. Res. Section Abstract Doc Link 12111832 Disease Relevance 0.86 Pain Relevance 0.57
However, unlike SHR, striatal DRD2 autoreceptors controlling dopamine synthesis are nonfunctional while DRD1 and DRD2 are downregulated by approximately 50% in the striatum of DAT-KO mice [171].
Negative_regulation (downregulated) of DRD1 in striatum associated with dopamine
5) Confidence 0.30 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.65 Pain Relevance 0.50
Decreased DRD1 function will alter transmission of signals in cortical and striatal circuits of SHR and impair dopamine-mediated cognitive function and reinforcement of appropriate behaviour.
Negative_regulation (Decreased) of DRD1 associated with cognitive disorder and dopamine
6) Confidence 0.30 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.10 Pain Relevance 0.28
We sought evidence for the requirement for dopamine systems in mediating this action of endogenous opioids by determining whether mice deficient in dopamine D-1 or D-2 receptors were able to display conditioned place aversion to naloxone.
Spec (whether) Negative_regulation (deficient) of dopamine D-1 associated with dopamine, narcan and endogenous opioid
7) Confidence 0.29 Published 2004 Journal Neuroscience Section Abstract Doc Link 14960355 Disease Relevance 0.07 Pain Relevance 0.76
Alternatively, altered calcyon function could impair DRD1/DRD5 function by affecting the switch from Gs to Gq coupling, thereby also altering intracellular calcium concentration.
Negative_regulation (impair) of DRD1
8) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.29 Pain Relevance 0.11
Increased intracellular calcium could interfere with calcyon translocation to the cell membrane and thereby impair DRD1/DRD5 function.
Negative_regulation (impair) of DRD1
9) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.28 Pain Relevance 0.11
These include the dopamine D1, D4 and D5 receptor (DRD1, DRD4, DRD5) genes, the ?
Negative_regulation (include) of DRD1 associated with dopamine
10) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.86 Pain Relevance 0.23
These include the dopamine D1, D4 and D5 receptor (DRD1, DRD4, DRD5) genes, the ?
Negative_regulation (include) of dopamine D1 associated with dopamine
11) Confidence 0.22 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.85 Pain Relevance 0.23
MDMA-induced locomotor activity, behavioral sensitization [37], [38], self-administration [39] and pERK stimulation [40] have all been shown to be reduced in D1 receptor antagonist-treated mice.
Negative_regulation (reduced) of D1 receptor associated with antagonist and eae
12) Confidence 0.17 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775951 Disease Relevance 0.16 Pain Relevance 0.35
The ability of morphine to stimulate Thr34 phosphorylation was prevented by blockade of dopamine D1 receptors.
Negative_regulation (blockade) of dopamine D1 associated with dopamine and morphine
13) Confidence 0.16 Published 2007 Journal Neuropsychopharmacology Section Abstract Doc Link 17251906 Disease Relevance 0.17 Pain Relevance 0.84
Phase delays induced by light pulses in the early subjective night were significantly reduced by blockade of dopamine D1 receptors.
Negative_regulation (blockade) of dopamine D1 associated with dopamine
14) Confidence 0.15 Published 2008 Journal PLoS Biology Section Body Doc Link PMC2567003 Disease Relevance 0.10 Pain Relevance 0.59
The results show that primary loss of D1 dopamine receptor-positive striatonigral pathway neurons is sufficient to generate a hyperkinetic phenotype.
Negative_regulation (loss) of D1 dopamine receptor in neurons associated with dopamine receptor
15) Confidence 0.13 Published 2000 Journal Neuroscience Section Abstract Doc Link 10682710 Disease Relevance 0.35 Pain Relevance 0.46
Dimebon also significantly inhibited Dopamine D1, D2S, D3 receptors, Imidazoline I2 receptor, Serotonin 5-HT2 and 5-HT2B receptors (70–80% inhibition).
Negative_regulation (inhibited) of Dopamine D1 associated with dopamine and serotonin
16) Confidence 0.02 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0.36 Pain Relevance 0.28

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