INT223739

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Context Info
Confidence 0.30
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.94
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Fgfr2) nucleus (Fgfr2) cell-cell signaling (Fgfr2)
cytoplasm (Fgfr2)
Anatomy Link Frequency
fibroblast 2
Fgfr2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cOX1 2 77.64 Quite High
Inflammation 21 62.56 Quite High
Osteoarthritis 38 58.44 Quite High
metalloproteinase 8 55.56 Quite High
Arthritis 15 47.36 Quite Low
cytokine 2 41.16 Quite Low
Pain 5 17.76 Low Low
Analgesic 2 8.24 Low Low
cINOD 10 5.00 Very Low Very Low Very Low
aspirin 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 45 73.20 Quite High
Cancer 5 72.20 Quite High
Shock 2 70.84 Quite High
Apoptosis 16 63.76 Quite High
INFLAMMATION 26 62.56 Quite High
Osteoarthritis 39 58.44 Quite High
Death 10 53.20 Quite High
Arthritis 15 47.36 Quite Low
Breast Cancer 1 38.80 Quite Low
Synovitis 1 31.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
FGFR2 Binding (binding) of in fibroblast
1) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.38 Pain Relevance 0.07
Tarnawski et al. [28] previously reported that rebamipide significantly upregulated the proangiogenic genes encoding vascular endothelial growth factor (VEGF), heparin binding epidermal growth-like factor (HB-EGF), fibroblast growth factor receptor-2 (FGFR2), and cyclooxygenase-2 (Cox2), as well as growth promoting genes, including insulin growth factor-1 (IGF-1).
fibroblast growth factor receptor-2 Binding (binding) of in fibroblast
2) Confidence 0.30 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243244 Disease Relevance 0.38 Pain Relevance 0.07
Four different high-affinity receptors (FGFR1, FGFR2, FGFR3, and FGFR4) bind FGF ligands and display varying patterns of expression [14].
FGFR2 Binding (bind) of
3) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575604 Disease Relevance 0.19 Pain Relevance 0.08

General Comments

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