INT223746

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.49
Pain Relevance 1.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
T cells 2
colons 1
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 211 99.74 Very High Very High Very High
Inflammation 249 99.40 Very High Very High Very High
rheumatoid arthritis 72 98.42 Very High Very High Very High
imagery 4 98.00 Very High Very High Very High
antagonist 26 94.72 High High
fibrosis 4 94.64 High High
Arthritis 21 85.84 High High
corticosteroid 13 77.52 Quite High
psoriasis 3 74.36 Quite High
metalloproteinase 9 51.20 Quite High
Disease Link Frequency Relevance Heat
Viral Infection 10 99.92 Very High Very High Very High
Cytomegalovirus Infection 10 99.64 Very High Very High Very High
INFLAMMATION 262 99.40 Very High Very High Very High
Chlamydia Infection 140 99.04 Very High Very High Very High
Disease 82 98.80 Very High Very High Very High
Rheumatoid Arthritis 72 98.42 Very High Very High Very High
Cancer 339 98.32 Very High Very High Very High
Infection 236 98.00 Very High Very High Very High
Granuloma 1 95.60 Very High Very High Very High
Fibrosis 4 94.64 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-10 plays an immunosuppressive role through interaction between antigen presenting cells and T cells [3],[41],[42].
IL-10 Binding (interaction) of in T cells
1) Confidence 0.36 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2749443 Disease Relevance 1.14 Pain Relevance 0
To find out whether the reduced LPS-response of inflammatory cytokines in the germfree mice is associated with IL-10, we measured IL-10 levels in serum after injection of LPS.
IL-10 Binding (associated) of associated with inflammation and cytokine
2) Confidence 0.35 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.10 Pain Relevance 0.10
These findings reiterate the critical role played by Socs3 in maintaining an inflammatory, anti-tumourigenic environment characterized by IL12 expression that is converted to a tumour promoting cytokine profile when Socs3 is unable to abate gp130 signaling following engagement of the IL10 family receptor components.
IL10 Binding (engagement) of associated with inflammation, cancer and cytokine
3) Confidence 0.32 Published 2010 Journal Cell Div Section Body Doc Link PMC2887830 Disease Relevance 0.87 Pain Relevance 0.22
Human cytomegalovirus (HCMV), a beta herpesvirus, encodes a viral IL-10 (cmvIL-10) that has only 27% homology to cellular IL-10, but is nevertheless capable of binding the IL-10 receptor and mediating downstream STAT1/STAT3 signaling [55].
IL-10 Binding (binding) of associated with cytomegalovirus infection
4) Confidence 0.31 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2270344 Disease Relevance 1.45 Pain Relevance 0
Structural identification of three of these differential metabolites using MS/MS, high resolution MS, and chemical synthesis has provided further insight into the metabolic changes associated with the IL10?
IL10 Binding (associated) of
5) Confidence 0.30 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC3005964 Disease Relevance 0.31 Pain Relevance 0.13
On the whole, it seems that the effect of Bv8 on the Th2 cytokines IL-4 and on IL-10 may not only be due to direct interactions with T lymphocytes, but may also be mediated by other cell types such as macrophages [19].
IL-10 Binding (interactions) of in T lymphocytes associated with cytokine
6) Confidence 0.20 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.13 Pain Relevance 0.15
To provide a more accurate assessment of C. jejuni induced colonic inflammation, colons of 14- day C. jejuni associated IL-10?
IL-10 Binding (associated) of in colons associated with inflammation
7) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.83 Pain Relevance 0.28
C. jejuni associated IL-10?
IL-10 Binding (associated) of
8) Confidence 0.19 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2760752 Disease Relevance 0.40 Pain Relevance 0.14
After incubation, supernatants were harvested and assayed for secreted IL-12 and IL-10 by commercial ELISA kits (Biosource International, CA, USA).
IL-10 Binding (assayed) of
9) Confidence 0.17 Published 2010 Journal J Transl Med Section Body Doc Link PMC2842246 Disease Relevance 0.32 Pain Relevance 0
IL-10 has been found to be associated with susceptibility to chlamydial infection and typical pathological changes caused by the infection such as granuloma formation and fibrosis [64].
IL-10 Binding (associated) of associated with fibrosis, granuloma, chlamydia infection and infection
10) Confidence 0.15 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2695819 Disease Relevance 2.04 Pain Relevance 0.08
IL-10 binds to the IL-10R1/IL-10R2 receptor complex and recruits both Jak1 and Tyk2 to activate STAT3 [125].
IL-10 Binding (binds) of
11) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592774 Disease Relevance 0.87 Pain Relevance 0.32
However, subjects with either rheumatoid arthritis or CrohnÂ’s disease did not experience significant clinical improvements after treatment with IL-10, that surprisingly stimulated IFN?
IL-10 Binding (treatment) of associated with rheumatoid arthritis and disease
12) Confidence 0.06 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 1.04 Pain Relevance 0.32

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