INT22375

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Context Info
Confidence 0.75
First Reported 1987
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 15.46
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PDGFA) extracellular region (PDGFA) embryo development (PDGFA)
cell-cell signaling (PDGFA)
Anatomy Link Frequency
platelets 8
endothelium 2
chondrocytes 1
fibroblasts 1
granulation 1
PDGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 248 100.00 Very High Very High Very High
cytokine 98 100.00 Very High Very High Very High
Nerve growth factor 44 100.00 Very High Very High Very High
fibrosis 134 99.10 Very High Very High Very High
Calcitonin gene-related peptide 10 96.56 Very High Very High Very High
Potency 7 91.64 High High
Cannabinoid 26 88.64 High High
Analgesic 4 86.32 High High
Bile 3 84.88 Quite High
ischemia 17 83.52 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 302 100.00 Very High Very High Very High
Atherosclerosis 34 99.64 Very High Very High Very High
Adhesions 46 99.62 Very High Very High Very High
Coagulation Disorder 7 99.52 Very High Very High Very High
Fibrosis 152 99.10 Very High Very High Very High
Primary Sclerosing Cholangitis 44 98.10 Very High Very High Very High
Increased Venous Pressure Under Development 52 96.88 Very High Very High Very High
Cirrhosis 62 96.52 Very High Very High Very High
Injury 236 96.32 Very High Very High Very High
Stress 179 95.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Platelet-derived growth factor (PDGF), secreted by activated platelets and lesion macrophages, is the most potent stimulus of VSMC attraction to the intima.
Localization (secreted) of PDGF in platelets
1) Confidence 0.75 Published 2008 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2582678 Disease Relevance 1.00 Pain Relevance 0.16
Platelet-derived growth factor (PDGF), secreted by activated platelets and lesion macrophages, is the most potent stimulus of VSMC attraction to the intima.
Localization (secreted) of Platelet-derived growth factor in platelets
2) Confidence 0.75 Published 2008 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2582678 Disease Relevance 1.01 Pain Relevance 0.16
To explain this finding, studies have demonstrated that lornoxicam inhibits polymorphonuclear (PMN)-leukocyte migration; inhibits the release of superoxide from human PMN-leukocytes; inhibits the release of platelet derived growth factor (PDGF) from human platelets and stimulates the synthesis of proteoglycans in cartilage in tissue culture.
Localization (release) of platelet derived growth factor in platelets
3) Confidence 0.63 Published 1990 Journal Postgrad Med J Section Abstract Doc Link 2284216 Disease Relevance 0.09 Pain Relevance 0.13
In order to simulate in vivo conditions and to understand the role of radiation-induced paracrine PDGF secretion, co-culture models consisting of fibroblasts and endothelial cells were employed.


Localization (secretion) of PDGF in fibroblasts
4) Confidence 0.56 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1458351 Disease Relevance 0.12 Pain Relevance 0.08
Through release of promoters and inhibitors of growth and differentiation of the VSMC, such as platelet-derived growth factor (PDGF) and ANG-II, endothelium also has an impact on vascular remodeling [11].
Localization (release) of platelet-derived growth factor in endothelium
5) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.13 Pain Relevance 0.14
Through release of promoters and inhibitors of growth and differentiation of the VSMC, such as platelet-derived growth factor (PDGF) and ANG-II, endothelium also has an impact on vascular remodeling [11].
Localization (release) of PDGF in endothelium
6) Confidence 0.44 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.14 Pain Relevance 0.14
VEGF, PDGF and NGF were also localized to chondrocytes.
Localization (localized) of PDGF in chondrocytes associated with nerve growth factor
7) Confidence 0.43 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.42 Pain Relevance 0.32
Platelet adhesion and degranulation release PDGF, which stimulates smooth muscle cell proliferation, synthetic functions, and vasoconstriction.
Localization (release) of PDGF in smooth muscle cell associated with increased venous pressure under development and adhesions
8) Confidence 0.35 Published 1987 Journal Cardiovasc Clin Section Abstract Doc Link 2955894 Disease Relevance 1.30 Pain Relevance 0
Platelets are the initiators of the clotting cascade, but they also release growth factors (including platelet-derived growth factor, PDGF) and cytokines to attract other cells required for healing.
Localization (release) of PDGF in platelet associated with coagulation disorder and cytokine
9) Confidence 0.32 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.67 Pain Relevance 0.14
Furthermore, there are a number of regulators of PSC activation: 1) paracrine factors such as cytokines (IL-1, MCP-1), growth factors (TGFbeta and PDGF) and endothelium-derived substances (endothelin-1) which are released by recruited inflammatory cells; and 2) factors secreted by destroyed parenchymal cells, such as acinar, endothelial and ductal cells [14], [15], [44]–[46].
Localization (released) of PDGF in parenchymal cells associated with inflammation, primary sclerosing cholangitis and cytokine
10) Confidence 0.30 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2253501 Disease Relevance 0.94 Pain Relevance 0.37
While the mechanism underlying chronic fibrosis is not fully known, vascular damage and the release of inflammatory cytokines and other factors such as platelet derived growth factor (PDGF), endothelial growth factor (EGF) and fibroblast growth factor (FGF) stimulate fibroblast activation which seems to initiate a pro-fibrotic cascade of events [5-10].
Localization (release) of PDGF in platelet associated with fibrosis, inflammation and cytokine
11) Confidence 0.22 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1891306 Disease Relevance 1.64 Pain Relevance 0.49
Using this technology we have previously shown that PDGF, angiogenin, RANTES, and many other cytokines and growth factors are secreted by platelets following thrombin activation [27].
Localization (secreted) of PDGF in platelets associated with cytokine
12) Confidence 0.22 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2846341 Disease Relevance 0 Pain Relevance 0.20
It has been shown that mast-cell secreted factors, specifically PDGF, could contribute to inflammation-associated fibrosis, inducing the expression of osteopontin by wound granulation tissue fibroblasts [171].
Localization (secreted) of PDGF in granulation associated with fibrosis, inflammation and injury
13) Confidence 0.21 Published 2010 Journal Theor Biol Med Model Section Body Doc Link PMC2945962 Disease Relevance 1.96 Pain Relevance 0.33
R [173], with cholangiocytes being able to secrete IL-6, TNF, IL-8 and MCP-1 as well as PDGF, ET-1, TGF?
Localization (secrete) of PDGF
14) Confidence 0.20 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 1.51 Pain Relevance 0.30
Combination approaches targeting the VEGF/VEGFR and the PDGF/PDGFR axes are thus very appealing [67].


Localization (targeting) of PDGF
15) Confidence 0.19 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2804796 Disease Relevance 0.92 Pain Relevance 0.03
In order to simulate in vivo conditions and to understand the role of radiation-induced paracrine PDGF secretion, co-culture models consisting of fibroblasts and endothelial cells were employed.


Localization (secretion) of PDGF in endothelial cells
16) Confidence 0.19 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1458351 Disease Relevance 0.12 Pain Relevance 0.08
Later [17] it was also proven that CS can slowly release recombinant human Platelet-Derived Growth Factor (rhPDGF-BB) over time, therefore supporting the hypothesis that CS-Platelet behaves as time-controlled releasing matrix for all the platelet derived factors.
Localization (release) of Platelet-Derived Growth Factor in Platelet
17) Confidence 0.18 Published 2007 Journal J Transl Med Section Body Doc Link PMC1831762 Disease Relevance 0 Pain Relevance 0.04
However, a laboratory analysis of human PRP samples demonstrated increased concentrations of PDGF, TGFbeta, VEGF, and EGF, while not showing an increase in IGF-1 [25].
Localization (concentrations) of PDGF
18) Confidence 0.11 Published 2008 Journal Curr Rev Musculoskelet Med Section Body Doc Link PMC2682411 Disease Relevance 0.22 Pain Relevance 0.05
The upstream factor overactivity could be due to intrinsic cell-signaling upregulation (constitutively active PDGF receptor), or due to an increase in external stimulus (eg, excess PDGF secretion by overlying keratinocytes).
Localization (secretion) of PDGF in keratinocytes
19) Confidence 0.10 Published 2008 Journal Eplasty Section Body Doc Link PMC2311454 Disease Relevance 0.14 Pain Relevance 0
Although the aim of this work was not the identification of the molecular effectors responsible for the angiogenic properties of EPC-CM, we have confirmed that EPC release key angiogenic molecules such as Angiogenin, HGF, IL-8, PDGF, SDF-1 and VEGF in culture.
Localization (release) of PDGF in HGF
20) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682571 Disease Relevance 0.23 Pain Relevance 0.03

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