INT223753

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.32
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.93
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Tlr4, Il10) extracellular space (Il10) signal transduction (Tlr4)
extracellular region (Il10) plasma membrane (Tlr4) cytoplasm (Tlr4)
Anatomy Link Frequency
Kupffer cells 4
Tlr4 (Mus musculus)
Il10 (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 3 99.24 Very High Very High Very High
Inflammation 28 94.00 High High
cytokine 46 92.96 High High
Analgesic 1 86.72 High High
IPN 1 85.96 High High
Inflammatory response 13 79.92 Quite High
agonist 21 46.32 Quite Low
antagonist 3 44.04 Quite Low
Central nervous system 22 5.00 Very Low Very Low Very Low
Inflammatory mediators 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 56 99.92 Very High Very High Very High
Creutzfeldt Jakob Disease 2 95.76 Very High Very High Very High
INFLAMMATION 47 94.00 High High
Targeted Disruption 9 88.80 High High
Prion Diseases 13 87.08 High High
Inflammatory Pain 1 85.96 High High
Gliosis 1 74.56 Quite High
Necrosis 5 59.92 Quite High
Cancer 6 59.56 Quite High
Mycobacterial Infection 3 25.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar differences to the in vivo results were observed in LPS-induced IL-10 production of Kupffer cells between GF and CV mice.
LPS Positive_regulation (induced) of Gene_expression (production) of IL-10 in Kupffer cells
1) Confidence 0.32 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.12 Pain Relevance 0.19
LPS-induced IL-10 production in Kupffer cells
LPS Positive_regulation (induced) of Gene_expression (production) of IL-10 in Kupffer cells
2) Confidence 0.32 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2243250 Disease Relevance 0.07 Pain Relevance 0.07
TLR4 signaling induces IL-10 production, and this may be the pathway by which TLR4 dysfunction may mediate the rapid progression of the disease [103, 104].
TLR4 Positive_regulation (induces) of Gene_expression (production) of IL-10 associated with disease
3) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913815 Disease Relevance 1.29 Pain Relevance 0.03
Adenosine-mediated activation of this receptor augmented IL-10 production by RAW264 cells in response to LPS [57].
LPS Positive_regulation (augmented) of Gene_expression (production) of IL-10 associated with adenocard
4) Confidence 0.02 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.45 Pain Relevance 0.49

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox