INT223829

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Context Info
Confidence 0.41
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 2.78
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSTM1, GSTP1) small molecule metabolic process (GSTM1, GSTP1) cytoplasm (GSTM1, GSTP1)
plasma membrane (GSTP1) nucleus (GSTP1) intracellular (GSTP1)
GSTM1 (Homo sapiens)
GSTP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 68 95.80 Very High Very High Very High
cytokine 4 51.28 Quite High
Inflammatory response 10 33.12 Quite Low
tolerance 1 8.16 Low Low
alcohol 10 5.00 Very Low Very Low Very Low
Inflammatory marker 6 5.00 Very Low Very Low Very Low
dorsal root ganglion 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
induced neuropathy 1 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hearing Impairment 15 100.00 Very High Very High Very High
INFLAMMATION 86 95.80 Very High Very High Very High
Nicotine Addiction 118 94.96 High High
Tinnitus 12 89.36 High High
Lung Cancer 2 88.88 High High
Disease 24 84.28 Quite High
Dysesthesia 13 77.84 Quite High
Cancer 19 57.92 Quite High
Stress 8 50.56 Quite High
Testicular Cancer 11 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The previous study by Ryberg and coworkers support the interaction between GSTM1 and GSTP1 genetic polymorphisms (30).
GSTM1 Binding (interaction) of GSTP1
1) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.82 Pain Relevance 0.20
This result suggests that there are interactions between GSTM1 and GSTP1 genetic polymorphisms, thus subjects with the combination of GSTM1 null and GSTP1 AG or GG genotypes are more susceptible to smoking-induced inflammation than those with the other genotype combinations.
GSTM1 Binding (interactions) of GSTP1 associated with nicotine addiction and inflammation
2) Confidence 0.41 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721922 Disease Relevance 0.99 Pain Relevance 0.19
In the subgroup of 173 TCSs in whom audiometry was performed such a beneficial effect of non-functional GSTM1 was found for objectively measured cisplatin-induced hearing impairment, which in addition was strongly associated with the genotype GSTP1-GG [22].
GSTM1 Binding (associated) of GSTP1 associated with hearing impairment
3) Confidence 0.34 Published 2007 Journal J Transl Med Section Body Doc Link PMC2245909 Disease Relevance 0.97 Pain Relevance 0

General Comments

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