INT22383

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Context Info
Confidence 0.48
First Reported 1987
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 59
Total Number 59
Disease Relevance 39.06
Pain Relevance 8.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL2) extracellular region (IL2) cell adhesion (IL2)
cell-cell signaling (IL2)
Anatomy Link Frequency
T cells 12
granulocyte 2
capillary 2
bone marrow 1
apoptotic cell 1
IL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 712 100.00 Very High Very High Very High
chemokine 76 100.00 Very High Very High Very High
opioid receptor 2 100.00 Very High Very High Very High
carpal tunnel syndrome 4 99.98 Very High Very High Very High
palliative 14 99.66 Very High Very High Very High
depression 42 99.42 Very High Very High Very High
Opioid 1 99.36 Very High Very High Very High
imagery 68 99.28 Very High Very High Very High
agonist 49 99.00 Very High Very High Very High
Inflammation 595 98.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 350 100.00 Very High Very High Very High
Disease 350 100.00 Very High Very High Very High
Infection 260 100.00 Very High Very High Very High
Metastasis 40 100.00 Very High Very High Very High
Necrosis 35 100.00 Very High Very High Very High
Carpal Tunnel Syndrome 4 99.98 Very High Very High Very High
Oral Tuberculosis 1 99.98 Very High Very High Very High
Atherosclerosis 105 99.92 Very High Very High Very High
Renal Cancer 151 99.42 Very High Very High Very High
Depression 48 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Many articles have reported that IL-2 was associated with the clinical mechanism of ulcerative colitis, but there seems no reports about such complications before.
IL-2 Binding (associated) of associated with inflammatory bowel disease
1) Confidence 0.48 Published 2009 Journal Nippon Hinyokika Gakkai Zasshi Section Abstract Doc Link 19663247 Disease Relevance 1.31 Pain Relevance 0.08
A mild reversible depression of cardiac function is also associated with IL-2 treatment.
IL-2 Binding (associated) of associated with depression
2) Confidence 0.48 Published 1989 Journal J. Clin. Oncol. Section Abstract Doc Link 2783338 Disease Relevance 0.67 Pain Relevance 0.05
The interaction of IL-2 with the Na+ channels is very fast (within ms) and it is suggested that it occurs when the Na+ channels are in the state of fast inactivation.
IL-2 Binding (interaction) of
3) Confidence 0.47 Published 1994 Journal Pflugers Arch. Section Abstract Doc Link 8146027 Disease Relevance 0 Pain Relevance 0.24
Intravenous high dose bolus therapy with interleukin-2 (IL2) is associated with low overall response rates (15%) and significant toxicity.
IL2 Binding (associated) of associated with toxicity
4) Confidence 0.47 Published 2003 Journal Melanoma Res. Section Abstract Doc Link 12777988 Disease Relevance 0.53 Pain Relevance 0
Intravenous high dose bolus therapy with interleukin-2 (IL2) is associated with low overall response rates (15%) and significant toxicity.
interleukin-2 Binding (associated) of associated with toxicity
5) Confidence 0.47 Published 2003 Journal Melanoma Res. Section Abstract Doc Link 12777988 Disease Relevance 0.53 Pain Relevance 0
This MAb identifies the IL-2 receptors by blocking the binding of radiolabelled IL-2 to T-cells.
IL-2 Binding (binding) of in T-cells
6) Confidence 0.45 Published 1990 Journal Headache Section Abstract Doc Link 2335478 Disease Relevance 0.31 Pain Relevance 0.31
In cell lines, it was thought that daclizumab blocked the interaction of IL2 and its receptor resulting in cytokine-deprivation-mediated apoptotic cell death.20 Additionally, based on in vivo data from mouse models, it was thought that daclizumab also exerted an effect through an FcR receptor mechanism.21
IL2 Binding (interaction) of in apoptotic cell associated with apoptosis, death and cytokine
7) Confidence 0.43 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004568 Disease Relevance 1.65 Pain Relevance 0.09
Terms for the interaction between IL-2 and vaccine, as well as for time were included.
IL-2 Binding (interaction) of
8) Confidence 0.39 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.34 Pain Relevance 0.03
For CD4+ T cell concentrations, statistical analysis showed no interaction between IL-2 and vaccine, but there was a main effect of IL-2 (p < 0.0001) and no effect of vaccine.
IL-2 Neg (no) Binding (interaction) of in T cell
9) Confidence 0.39 Published 2007 Journal PLoS Clinical Trials Section Body Doc Link PMC1783674 Disease Relevance 0.18 Pain Relevance 0
Because the aromatic residues at the N-termini of opioid peptides are crucial for their binding to the opioid receptors, all nine aromatic residues in IL-2 were mutated by site-directed mutagenesis and both the analgesic activity and the immune activity of the wild-type and mutated IL-2 were tested.
IL-2 Binding (binding) of associated with analgesic, opioid receptor and opioid
10) Confidence 0.37 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9015358 Disease Relevance 0 Pain Relevance 0.55
In other neoplasms, the indication for adjuvant IL-2 has been sporadic and does not allow conclusions to be drawn.
IL-2 Binding (indication) of associated with cancer
11) Confidence 0.37 Published 2006 Journal Anticancer Drugs Section Abstract Doc Link 16317284 Disease Relevance 1.53 Pain Relevance 0.07
IL-2 was mainly used in metastatic disease, associated with other immunotherapy or chemotherapy schedules.
IL-2 Binding (associated) of associated with metastasis
12) Confidence 0.37 Published 2006 Journal Anticancer Drugs Section Abstract Doc Link 16317284 Disease Relevance 1.59 Pain Relevance 0
The activity of IL-2 in monotherapy or in association with immunotherapy is clinically relevant in hepatocarcinoma, mesothelioma and in malignant overflows as palliative treatment.
IL-2 Binding (association) of associated with malignant neoplastic disease, lung cancer and palliative
13) Confidence 0.37 Published 2006 Journal Anticancer Drugs Section Abstract Doc Link 16317284 Disease Relevance 1.42 Pain Relevance 0.10
IL-2, originally identified as a T-cell growth factor, is now recognized as a pivotal cytokine in T-cell dependent immune responses [8].
IL-2 Binding (recognized) of in T-cell associated with cytokine
14) Confidence 0.37 Published 2008 Journal Chiropr Osteopat Section Body Doc Link PMC2423359 Disease Relevance 0.15 Pain Relevance 0.20
Treatment with IL-2 is associated with significant cardiorespiratory effects, as well as a leaky capillary syndrome requiring careful fluid management.
IL-2 Binding (associated) of in capillary associated with syndrome
15) Confidence 0.37 Published 1989 Journal J. Clin. Oncol. Section Abstract Doc Link 2783338 Disease Relevance 0.40 Pain Relevance 0.04
Gastrointestinal perforations associated with interleukin-2 administration.
interleukin-2 Binding (associated) of
16) Confidence 0.37 Published 2004 Journal J. Immunother. Section Title Doc Link 15076143 Disease Relevance 0.39 Pain Relevance 0.06
An association between SNP's in IL23R (IL-23 receptor ?
IL-2 Binding (receptor) of
17) Confidence 0.36 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2001184 Disease Relevance 1.64 Pain Relevance 0.28
In order to assess the palliative and therapeutic activity of IL-2 in unresectable pleural malignant mesothelioma with pleural effusion, we performed a phase II study on 31 consecutive patients (M/F 16/15; median age 61 years, range 40-84; PS ECOG 0 n=7; ECOG 1 n=15; ECOG 2 n=9; stage IA n=13; IB n=9; II n=7; IV=2) who received first-line therapy with intrapleural repeated instillation of 9000000 I.U.
IL-2 Binding (activity) of associated with pleural effusion, malignant neoplastic disease, lung cancer and palliative
18) Confidence 0.36 Published 2001 Journal Lung Cancer Section Abstract Doc Link 11165411 Disease Relevance 1.55 Pain Relevance 0.17
Furthermore, immunotherapy with interleukin-2 and/or interferons seems to demonstrate a great efficacy in solid tumors and malignancies of the blood.
interleukin-2 Binding (immunotherapy) of in blood associated with solid tumor
19) Confidence 0.36 Published 1996 Journal Arch Gerontol Geriatr Section Abstract Doc Link 18653084 Disease Relevance 0.75 Pain Relevance 0.16
Multifocal metastases of recurrent renal cell carcinoma successfully treated with a combination of low dose interleukin-2, alpha-interferon and radiotherapy.
interleukin-2 Binding (combination) of associated with renal cancer and metastasis
20) Confidence 0.34 Published 2005 Journal Int. J. Urol. Section Title Doc Link 16351657 Disease Relevance 0.89 Pain Relevance 0.13

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