INT223866

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2009
Negated 0
Speculated 2
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.75
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk1) mitochondrion (Mapk1) protein complex (Mapk1)
cytoplasm (Mapk1) cytosol (Mapk1) signal transduction (Mapk1)
Anatomy Link Frequency
ACC 2
Ltp (Mus musculus)
Mapk1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 260 100.00 Very High Very High Very High
Anterior cingulate cortex 150 100.00 Very High Very High Very High
Lasting pain 22 98.72 Very High Very High Very High
Hippocampus 21 95.60 Very High Very High Very High
Inflammation 8 95.16 Very High Very High Very High
IPN 5 90.40 High High
nMDA receptor 52 87.12 High High
Somatosensory cortex 12 69.44 Quite High
nociceptor 3 58.16 Quite High
Peripheral sensitization 1 48.40 Quite Low
Disease Link Frequency Relevance Heat
Pain 34 98.28 Very High Very High Very High
INFLAMMATION 8 95.16 Very High Very High Very High
Inflammatory Pain 5 90.40 High High
Nociception 7 87.96 High High
Injury 7 85.44 High High
Hypersensitivity 9 69.44 Quite High
Anxiety Disorder 12 5.00 Very Low Very Low Very Low
Targeted Disruption 8 5.00 Very Low Very Low Very Low
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Neuropathic Pain 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we examined whether LTP in ACC requires the activation of ERK.
LTP Spec (whether) Positive_regulation (requires) of Spec (whether) Positive_regulation (activation) of ERK in ACC associated with long-term potentiation and anterior cingulate cortex
1) Confidence 0.46 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2245920 Disease Relevance 0.08 Pain Relevance 0.73
Considering the importance of ERK in regulating gene expression, the ERK activation may be required for L-LTP.
L-LTP Positive_regulation (required) of Positive_regulation (activation) of ERK associated with long-term potentiation
2) Confidence 0.33 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.91
Considering the fact that ERK activity is required for ACC LTP [14], it is conceivable that activity-dependent LTP may contribute to activation of ERK1/2 in the ACC in animal models of persistent pain.
LTP Spec (may) Positive_regulation (contribute) of Positive_regulation (activation) of ERK1/2 associated with pain, lasting pain, long-term potentiation and anterior cingulate cortex
3) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734546 Disease Relevance 0.67 Pain Relevance 0.97

General Comments

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