INT223868

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Context Info
Confidence 0.17
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.34
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk1, Creb1) nucleus (Mapk1, Creb1) transcription factor binding (Mapk1, Creb1)
nucleoplasm (Mapk1) DNA binding (Creb1) protein complex (Mapk1)
Anatomy Link Frequency
hepatocytes 1
liver 1
neurons 1
Mapk1 (Mus musculus)
Creb1 (Mus musculus)
Pain Link Frequency Relevance Heat
Anterior cingulate cortex 34 92.48 High High
long-term potentiation 104 92.04 High High
Hippocampus 9 87.56 High High
nMDA receptor 14 69.52 Quite High
Calcium channel 1 64.92 Quite High
Glutamate 1 59.52 Quite High
Glutamate receptor 1 47.40 Quite Low
dopamine receptor 1 45.92 Quite Low
Lasting pain 4 33.40 Quite Low
Spinal sensitization 1 32.72 Quite Low
Disease Link Frequency Relevance Heat
Insulin Resistance 42 95.24 Very High Very High Very High
Stress 7 50.00 Quite Low
Injury 1 33.92 Quite Low
Pain 5 33.40 Quite Low
Impaired Glucose Tolerance 20 18.44 Low Low
Diabetes Mellitus 12 5.00 Very Low Very Low Very Low
Body Weight 8 5.00 Very Low Very Low Very Low
Anxiety Disorder 6 5.00 Very Low Very Low Very Low
Obesity 4 5.00 Very Low Very Low Very Low
Hyperglycemia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies showed that ROS phosphorylates and activates MAPKs in both hepatocytes and liver (5,24–26) and that ERK and p38 MAPK activate CREB.
ERK Positive_regulation (activate) of CREB in liver
1) Confidence 0.17 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.17 Pain Relevance 0
Activated ERK/MAPK likely has multiple targets including cAMP response element binding protein (CREB) that is required for long-term synaptic changes in neurons [4].
ERK Positive_regulation (required) of CREB in neurons
2) Confidence 0.07 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.68
Previous studies showed that ROS phosphorylates and activates MAPKs in both hepatocytes and liver (5,24–26) and that ERK and p38 MAPK activate CREB.
ERK Positive_regulation (activate) of CREB in hepatocytes
3) Confidence 0.06 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.17 Pain Relevance 0

General Comments

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