INT22388
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
MA-2029 concentration-dependently inhibited the binding of [125 I]motilin to motilin receptors in a homogenate of rabbit colon smooth muscle tissue and membranes of HEK 293 cells expressing human motilin receptors. | |||||||||||||||
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Studies have shown that motilin receptor is expressed in the enteric neurons of the colon [10,13] and plasma motilin concentration is reduced in adults with chronic constipation [14]. | |||||||||||||||
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SK-896 ([Leu(13)]motilin-Hse) is a new human motilin analogue synthesized by Escherichia coli using a biotechnological method. | |||||||||||||||
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SK-896 ([Leu(13)]motilin-Hse) is a new human motilin analogue synthesized by Escherichia coli using a biotechnological method. | |||||||||||||||
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In two patients there was no detectable motilin immunoreactivity and in one patient only sparse in the mucosa and the smooth muscle. | |||||||||||||||
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It is possible that the colon motilin receptors may have reduced affinity for erythromycin compared to the antral nerves or the expression of motilin receptor may be reduced in the colon. | |||||||||||||||
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Gallbladder volume and plasma levels of CCK, PP, motilin, gastrin, neurotensin, cholylglycine were measured regularly. | |||||||||||||||
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Motilin is a 22-amino-acid peptide synthesized from endocrine cells of the duodeno-jejunal mucosa. | |||||||||||||||
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Structurally, ghrelin resembles motilin. | |||||||||||||||
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IHC were performed on deparaffinized spleen, MLN or small intestine sections, with primary mAb (supplemental Table S2). | |||||||||||||||
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The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge. | |||||||||||||||
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PP and MLN DCs expressed elevated levels of CXCL9 and CXCL11, but not CXCL10, during Mycobacteria-enhanced colitis as indicated by their relative mean fluorescent intensities (Figure 5A). | |||||||||||||||
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, there were significantly more numbers of MLN and PP CD8? | |||||||||||||||
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This response is enhanced or maintained by high numbers of MLN and PP CD8? | |||||||||||||||
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The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge. | |||||||||||||||
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In the present study, we show that CXCL9 and CXCL11 are predominantly produced by DCs in the MLN as well as in PP and to a lesser degree in the intestinal LP. | |||||||||||||||
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General Comments
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