INT22388

Context Info Confidence 0.75 First Reported 1990 Last Reported 2010 Negated 2 Speculated 0 Reported most in Body Documents 15 Total Number 16 Disease Relevance 4.86 Pain Relevance 1.14

extracellular region (MLN) cell-cell signaling (MLN)

Anatomy Link Frequency plasma 2 smooth muscle 1 colon 1 endocrine cells 1 small intestine 1 MLN (Homo sapiens)

Pain Link Frequency Relevance Heat Neuropeptide 5 92.32 substance P 2 91.00 Dynorphin 1 88.80 cytokine 81 88.60 Crohn's disease 150 87.32 Calcitonin gene-related peptide 1 86.72 Somatostatin 1 83.36 Enkephalin 1 82.28 antagonist 7 80.48 Inflammation 67 77.48

Disease Link Frequency Relevance Heat Disease 239 99.40 Colitis 414 99.30 Constipation 30 95.84 Acquired Immune Deficiency Syndrome Or Hiv Infection 32 90.16 INFLAMMATION 55 77.48 Irritable Bowel Syndrome / Irritable Bowel Syndrome Super / Visceral Pain 2 75.00 Recurrence 2 63.56 Functional Bowel Disorder 5 56.44 Fecal Incontinence 6 55.56 Inflammatory Bowel Disease 114 53.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

MA-2029 concentration-dependently inhibited the binding of [125 I]motilin to motilin receptors in a homogenate of rabbit colon smooth muscle tissue and membranes of HEK 293 cells expressing human motilin receptors.

Gene_expression (expressing) of motilin in smooth muscle tissue

1) Confidence 0.75 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 18164286 Disease Relevance 0 Pain Relevance 0.20

Studies have shown that motilin receptor is expressed in the enteric neurons of the colon [10,13] and plasma motilin concentration is reduced in adults with chronic constipation [14].

Gene_expression (expressed) of motilin in plasma associated with constipation

2) Confidence 0.75 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.45 Pain Relevance 0.07

SK-896 ([Leu(13)]motilin-Hse) is a new human motilin analogue synthesized by Escherichia coli using a biotechnological method.

Gene_expression (synthesized) of motilin-Hse

3) Confidence 0.60 Published 2000 Journal Pharmacology Section Abstract Doc Link 10754449 Disease Relevance 0 Pain Relevance 0.03

SK-896 ([Leu(13)]motilin-Hse) is a new human motilin analogue synthesized by Escherichia coli using a biotechnological method.

Gene_expression (synthesized) of motilin

4) Confidence 0.60 Published 2000 Journal Pharmacology Section Abstract Doc Link 10754449 Disease Relevance 0 Pain Relevance 0.03

In two patients there was no detectable motilin immunoreactivity and in one patient only sparse in the mucosa and the smooth muscle.

Neg (no) Gene_expression (detectable) of motilin in smooth muscle

5) Confidence 0.60 Published 1990 Journal Int J Colorectal Dis Section Abstract Doc Link 2286799 Disease Relevance 0.31 Pain Relevance 0.42

It is possible that the colon motilin receptors may have reduced affinity for erythromycin compared to the antral nerves or the expression of motilin receptor may be reduced in the colon.

Gene_expression (expression) of motilin in colon

6) Confidence 0.58 Published 2008 Journal BMC Gastroenterol Section Body Doc Link PMC2529327 Disease Relevance 0.16 Pain Relevance 0

Gallbladder volume and plasma levels of CCK, PP, motilin, gastrin, neurotensin, cholylglycine were measured regularly.

Gene_expression (levels) of motilin in plasma

7) Confidence 0.40 Published 2005 Journal Neurogastroenterol. Motil. Section Body Doc Link 16185316 Disease Relevance 0 Pain Relevance 0

Motilin is a 22-amino-acid peptide synthesized from endocrine cells of the duodeno-jejunal mucosa.

Gene_expression (synthesized) of Motilin in endocrine cells

8) Confidence 0.40 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0

Structurally, ghrelin resembles motilin.

Gene_expression (resembles) of motilin

9) Confidence 0.39 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925306 Disease Relevance 0 Pain Relevance 0

IHC were performed on deparaffinized spleen, MLN or small intestine sections, with primary mAb (supplemental Table S2).

Gene_expression (sections) of MLN in small intestine

10) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.09 Pain Relevance 0

The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.

Gene_expression (subsets) of MLN associated with colitis

11) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.61 Pain Relevance 0.06

PP and MLN DCs expressed elevated levels of CXCL9 and CXCL11, but not CXCL10, during Mycobacteria-enhanced colitis as indicated by their relative mean fluorescent intensities (Figure 5A).

Gene_expression (expressed) of MLN associated with colitis

12) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.51 Pain Relevance 0.08

, there were significantly more numbers of MLN and PP CD8?

Gene_expression (numbers) of MLN

13) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.70 Pain Relevance 0.03

This response is enhanced or maintained by high numbers of MLN and PP CD8?

Gene_expression (numbers) of MLN

14) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.88 Pain Relevance 0.11

The numbers of MLN and LP DCs subsets expressing CXCL9 and CXCL11 after the onset of colitis were significantly increased during live Mycobacteria-enhanced colitis than in the other groups with the exception of MLN CXCL10+ myeloid DCs that were elevated following live bacterial challenge.

Neg (exception) Gene_expression (exception) of MLN associated with colitis

15) Confidence 0.06 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.60 Pain Relevance 0.03

In the present study, we show that CXCL9 and CXCL11 are predominantly produced by DCs in the MLN as well as in PP and to a lesser degree in the intestinal LP.

Gene_expression (produced) of MLN

16) Confidence 0.05 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 0.47 Pain Relevance 0.08

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