INT22389

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Context Info
Confidence 0.61
First Reported 1982
Last Reported 2009
Negated 3
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 4.39
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MLN) cell-cell signaling (MLN)
Anatomy Link Frequency
plasma 3
T cell 2
smooth muscle 1
gastric antrum 1
alimentary tract 1
MLN (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 6 100.00 Very High Very High Very High
narcan 5 99.84 Very High Very High Very High
Cholecystokinin 4 98.16 Very High Very High Very High
cytokine 43 97.56 Very High Very High Very High
substance P 6 95.84 Very High Very High Very High
Bile 1 95.04 Very High Very High Very High
Neuropeptide 5 93.68 High High
Enkephalin 6 90.08 High High
Dynorphin 1 88.36 High High
Crohn's disease 50 88.12 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 6 99.52 Very High Very High Very High
Infection 84 99.24 Very High Very High Very High
Apoptosis 16 96.24 Very High Very High Very High
Death 23 95.20 Very High Very High Very High
Constipation 4 94.76 High High
Gastric Motility Disorder 1 94.52 High High
Splenomegaly 4 89.76 High High
Disease 83 88.12 High High
Colitis 138 85.84 High High
Paratuberculosis 40 79.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Plasma motilin was not altered by naloxone or loperamide, and neither drug had any effect on basal gastric acid secretion, duodenal output of amylase and bile salt or duodenogastric reflux.
Neg (not) Regulation (altered) of motilin in Plasma associated with bile, narcan and gastric motility disorder
1) Confidence 0.61 Published 1983 Journal Eur. J. Clin. Invest. Section Abstract Doc Link 6191994 Disease Relevance 0.09 Pain Relevance 0.62
There was a significant rise in pancreatic polypeptide compared to a control infusion, but no change in plasma insulin, pancreatic glucagon, gastrin, somatostatin, motilin, neurotensin, gastric inhibitory peptide, or cholecystokinin was seen.
Neg (no) Regulation (change) of motilin in plasma associated with somatostatin and cholecystokinin
2) Confidence 0.44 Published 1984 Journal Clin. Endocrinol. (Oxf) Section Abstract Doc Link 6147213 Disease Relevance 0 Pain Relevance 0.19
We conclude that EM574 directly stimulates smooth muscle cell contraction by acting on motilin receptors in the human gastric antrum in vitro.
Regulation (acting) of motilin in gastric antrum
3) Confidence 0.27 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7965757 Disease Relevance 0 Pain Relevance 0.15
In two patients there was no detectable motilin immunoreactivity and in one patient only sparse in the mucosa and the smooth muscle.
Neg (no) Regulation (immunoreactivity) of motilin in smooth muscle
4) Confidence 0.24 Published 1990 Journal Int J Colorectal Dis Section Abstract Doc Link 2286799 Disease Relevance 0.31 Pain Relevance 0.41
Additionally, in the cerebral ganglion only, there were cells immunoreactive for beta-endorphin, VIP, motilin and human prolactin. 5-HT positive cells, however, were restricted to the alimentary tract.
Regulation (immunoreactive) of motilin in alimentary tract associated with ganglion cysts
5) Confidence 0.11 Published 1982 Journal Cell Tissue Res. Section Abstract Doc Link 6279305 Disease Relevance 0.47 Pain Relevance 0.55
One of the gastrointestinal motility regulatory factors has been assumed to be the induction of changes in the levels of peptides (gastrin, somatostatin and motilin) in plasma.
Regulation (changes) of motilin in plasma associated with somatostatin
6) Confidence 0.07 Published 2005 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 15969937 Disease Relevance 0 Pain Relevance 0.40
These innate and adaptive immune responses coincide with Mycobacteria-specific humoral and cellular responses and modulation of mesenteric lymph node (MLN), Peyer's patch (PP) and lamina propria (LP) Th1-associated cytokines and CXCR3 ligands expressed by DCs, T cells, neutrophils and NK/NKT cell subsets following Mycobacteria challenge of otherwise specific pathogen-free mice.


Regulation (modulation) of MLN in T cells associated with cytokine
7) Confidence 0.02 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.00 Pain Relevance 0.33
Taken together, the data discussed above show that SCLN and MLN lymphocytes are distinctly affected in T. cruzi acute infection, with different patterns of T cell activation, proliferation, cytokine responses, and cell death.


Regulation (affected) of MLN in T cell associated with death, infection and cytokine
8) Confidence 0.01 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2700264 Disease Relevance 1.51 Pain Relevance 0.09
These innate and adaptive immune responses coincide with Mycobacteria-specific humoral and cellular responses and modulation of mesenteric lymph node (MLN), Peyer's patch (PP) and lamina propria (LP) Th1-associated cytokines and CXCR3 ligands expressed by DCs, T cells, neutrophils and NK/NKT cell subsets following Mycobacteria challenge of otherwise specific pathogen-free mice.


Regulation (modulation) of MLN in neutrophils associated with cytokine
9) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2443107 Disease Relevance 1.00 Pain Relevance 0.33

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