INT223902

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Context Info
Confidence 0.67
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 17.08
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ifi35) molecular_function (Ifi35) biological_process (Ifi35)
Anatomy Link Frequency
vasculature 2
plasma 1
Ifi35 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 13 82.36 Quite High
dexamethasone 12 79.20 Quite High
antagonist 2 76.64 Quite High
imagery 70 76.16 Quite High
cytokine 1 54.84 Quite High
Taxol 14 5.00 Very Low Very Low Very Low
Pain 10 5.00 Very Low Very Low Very Low
Buprenorphine 10 5.00 Very Low Very Low Very Low
methotrexate 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2448 100.00 Very High Very High Very High
Hyperplasia 10 99.84 Very High Very High Very High
Solid Tumor 24 99.64 Very High Very High Very High
Severe Combined Immunodeficiency 43 98.52 Very High Very High Very High
Hypoxia 220 98.08 Very High Very High Very High
Melanoma 3 97.96 Very High Very High Very High
Colon Cancer 4 97.32 Very High Very High Very High
Experimental Melanoma 10 96.92 Very High Very High Very High
Metastasis 213 96.44 Very High Very High Very High
Breast Cancer 3 96.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, when grown i/m, the IFP in the MMTV-PYMT tumours was significantly increased.
Positive_regulation (increased) of IFP associated with cancer
1) Confidence 0.67 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.54 Pain Relevance 0
It is clear that factors influencing tumour IFP are complex and that further study is required to reveal the mechanisms that elevate IFP and its importance in therapeutic response either as a stand-alone factor or in combination with other factors.


Positive_regulation (elevate) of IFP associated with cancer
2) Confidence 0.67 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 0.89 Pain Relevance 0
These data, coupled with the breadth of data demonstrating elevated IFP in a wide range of human tumours [7,18,19,21-25], designate high tumour IFP as an important therapeutic problem.
Positive_regulation (elevated) of IFP associated with cancer
3) Confidence 0.67 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.33 Pain Relevance 0
Solid tumours show interstitial fluid pressures (IFP) that are elevated above that of normal tissues.
Positive_regulation (elevated) of IFP associated with solid tumor
4) Confidence 0.59 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 0.47 Pain Relevance 0
Whether the lack of correlation in these parameters is indicative of no involvement in the development of tumour IFP remains uncertain, however, since the parameters are interdependent and may act together to elevate IFP.
Positive_regulation (elevate) of IFP associated with cancer
5) Confidence 0.59 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.02 Pain Relevance 0
Nevertheless, the heterogeneity of IFP in individual tumours growing under similar conditions suggests that IFP is probably influenced to a large extent by the stochastic nature of vascular development and remodelling during tumour growth.
Positive_regulation (influenced) of IFP associated with cancer
6) Confidence 0.48 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.39 Pain Relevance 0
Elevated tumour IFP is a consequence of complex pathophysiologic interactions between the tumour vasculature and the interstitium.
Positive_regulation (Elevated) of IFP in vasculature associated with cancer
7) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.89 Pain Relevance 0
In addition, proliferation was assessed using the proliferation marker Ki67, as it has been suggested that genes involved in cellular proliferation may be upregulated in tumours with higher IFP values [51,52].
Positive_regulation (upregulated) of IFP associated with cancer and hyperplasia
8) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.67 Pain Relevance 0
There is increasing interest in the adverse effects of elevated tumour IFP on drug delivery and treatment response.
Positive_regulation (elevated) of IFP associated with cancer
9) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 1.38 Pain Relevance 0.07
Elevated tumour IFP plays a role in the pathophysiological microenvironment that characterises solid tumours contributing to disease progression and therapeutic resistance [3,6-9].
Positive_regulation (Elevated) of IFP associated with cancer, solid tumor and disease progression
10) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2245966 Disease Relevance 0.89 Pain Relevance 0.04
This increased IFP forms a barrier for transcapillary transport thereby impairing the uptake of cytotoxic agents [23].
Positive_regulation (increased) of IFP
11) Confidence 0.04 Published 2008 Journal Cancer Chemother Pharmacol Section Body Doc Link PMC2691802 Disease Relevance 1.21 Pain Relevance 0.06
A potentially increased IFP at the tumor site was thought to be reflected by differences between tumor and plasma exposures of unbound platinum in our study.
Positive_regulation (increased) of IFP in plasma associated with cancer
12) Confidence 0.03 Published 2008 Journal Cancer Chemother Pharmacol Section Body Doc Link PMC2691802 Disease Relevance 1.38 Pain Relevance 0.10
Due to fragile vasculature which is more permeable than normal vasculature, the interstitial fluid pressure (IFP) is known to be increased in many solid tumors compared to adjacent normal tissue.
Positive_regulation (increased) of IFP in vasculature associated with solid tumor
13) Confidence 0.03 Published 2008 Journal Cancer Chemother Pharmacol Section Body Doc Link PMC2691802 Disease Relevance 1.18 Pain Relevance 0.03
Moreover, overexpression of PDGF can also contribute to increased IFP of tumors, since PDGF inhibition decreases tumor IFP [6].
Positive_regulation (increased) of IFP associated with cancer
14) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781164 Disease Relevance 0.82 Pain Relevance 0.10

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