INT223921

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.83
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cux1) nucleus (Cux1) protein binding, bridging (Cux1)
DNA binding (Cux1) cytoplasm (Cux1)
Anatomy Link Frequency
brain 2
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 415 99.98 Very High Very High Very High
depression 95 98.32 Very High Very High Very High
Serotonin 25 92.00 High High
sSRI 40 89.92 High High
agonist 55 89.76 High High
monoamine 65 87.76 High High
Neurotransmitter 15 87.36 High High
fluoxetine 55 57.72 Quite High
Desipramine 30 55.36 Quite High
Kinase C 20 54.40 Quite High
Disease Link Frequency Relevance Heat
Depression 95 98.32 Very High Very High Very High
Affective Disorder 10 94.84 High High
Disease 15 85.16 High High
Anxiety Disorder 5 30.00 Quite Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 10 5.00 Very Low Very Low Very Low
Toxicity 5 5.00 Very Low Very Low Very Low
Suicidal Behaviour 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This implies that the compounds do not inhibit IP breakdown (otherwise they would have substituted for Li+), and that their effects on IP accumulation is probably secondary and passive to the enhanced production of upstream CDP-DG and PI substrates.
Positive_regulation (enhanced) of Gene_expression (production) of CDP
1) Confidence 0.49 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.05 Pain Relevance 0.40
Although CDP-DG production induced by the antidepressants may be derived from phosphoinositide breakdown, it is not impossible that the CDP-DG pool may be generated from additional endogenous sources.
Positive_regulation (induced) of Gene_expression (production) of CDP associated with antidepressant
2) Confidence 0.40 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.06 Pain Relevance 0.63
Antidepressants elicit greater stimulation of CDP-diacylglycerol production than IP formation
Positive_regulation (stimulation) of Gene_expression (production) of CDP associated with antidepressant
3) Confidence 0.38 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.52
Diverse antidepressants increase CDP-diacylglycerol production and phosphatidylinositide resynthesis in depression-relevant regions of the rat brain

Background

Positive_regulation (increase) of Gene_expression (production) of CDP in brain associated with antidepressant and depression
4) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Title Doc Link PMC2245968 Disease Relevance 0.62 Pain Relevance 0.51
Chemically diverse antidepressant agents increase CDP-diacylglycerol production
Positive_regulation (increase) of Gene_expression (production) of CDP associated with antidepressant
5) Confidence 0.33 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.10 Pain Relevance 0.30

General Comments

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