INT223925

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpina1) extracellular region (Serpina1) endoplasmic reticulum (Drd1a)
plasma membrane (Drd1a) nucleus (Drd1a) intracellular (Drd1a)
Anatomy Link Frequency
brain 2
Drd1a (Rattus norvegicus)
Serpina1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 11 100.00 Very High Very High Very High
fluoxetine 11 91.48 High High
antidepressant 83 89.04 High High
sSRI 8 71.84 Quite High
Desipramine 6 58.36 Quite High
depression 19 50.00 Quite Low
Hippocampus 4 12.80 Low Low
monoamine 13 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 19 50.00 Quite Low
Toxicity 1 30.16 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Suicidal Behaviour 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To validate the effects of U73122, we also tested the compound against the action of SKF38393, a D1 receptor agonist that is known to induce PI hydrolysis in these brain tissues [14,65].
D1 receptor Positive_regulation (induce) of Gene_expression (hydrolysis) of PI in brain associated with agonist
1) Confidence 0.01 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.51

General Comments

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