INT223930

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.35
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Akt1, Pik3cb) cytosol (Akt1, Pik3cb) signal transduction (Akt1, Pik3cb)
nucleus (Akt1, Pik3cb) nucleoplasm (Akt1) transport (Akt1)
Anatomy Link Frequency
brain 1
Akt1 (Rattus norvegicus)
Pik3cb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 83 85.12 High High
depression 19 81.28 Quite High
monoamine 13 44.08 Quite Low
fluoxetine 11 5.00 Very Low Very Low Very Low
agonist 11 5.00 Very Low Very Low Very Low
sSRI 8 5.00 Very Low Very Low Very Low
Desipramine 6 5.00 Very Low Very Low Very Low
Serotonin 5 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Suicidal Behaviour 1 97.76 Very High Very High Very High
Neurodegenerative Disease 2 96.76 Very High Very High Very High
Depression 19 81.28 Quite High
Disease 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study determined that the activity of PI3K and its downstream target, Akt, is decreased in postmortem brain tissues of depressed suicide victims [74].
Akt Spec (determined) Binding (activity) of PI3K in brain associated with suicidal behaviour
1) Confidence 0.07 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0.35 Pain Relevance 0.26

General Comments

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