INT223936

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (HSPG2) protein binding, bridging (Cux1) DNA binding (Cux1)
extracellular matrix organization (HSPG2) cytoplasm (Cux1) lipid metabolic process (HSPG2)
HSPG2 (Homo sapiens)
Cux1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antidepressant 83 100.00 Very High Very High Very High
Serotonin 5 64.04 Quite High
sSRI 8 61.96 Quite High
depression 19 50.00 Quite Low
agonist 11 46.92 Quite Low
monoamine 13 5.00 Very Low Very Low Very Low
fluoxetine 11 5.00 Very Low Very Low Very Low
Desipramine 6 5.00 Very Low Very Low Very Low
Kinase C 4 5.00 Very Low Very Low Very Low
Hippocampus 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Depression 19 50.00 Quite Low
Disease 3 5.00 Very Low Very Low Very Low
Urological Neuroanatomy 2 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 2 5.00 Very Low Very Low Very Low
Affective Disorder 2 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Suicidal Behaviour 1 5.00 Very Low Very Low Very Low
Anxiety Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that, while the integrity of the phosphoinositide pool is essential to the full effect of antidepressant agents on CDP-DG (based on the neomycin data), the PLC-accessible pool of phosphoinositides may not be the only source of antidepressant-mediated CDP-DG production (based on the U73122 data).
PLC Positive_regulation (mediated) of Gene_expression (production) of CDP associated with antidepressant
1) Confidence 0.03 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2245968 Disease Relevance 0 Pain Relevance 0.46

General Comments

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