INT223958

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.66
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 6.57
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 2
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 72 98.76 Very High Very High Very High
cytokine 16 76.60 Quite High
fibrosis 4 74.24 Quite High
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 124 99.84 Very High Very High Very High
Osteogenic Sarcomas 12 99.44 Very High Very High Very High
Pancreatitis 72 98.76 Very High Very High Very High
Cancer 60 98.56 Very High Very High Very High
Osteoporosis 4 97.28 Very High Very High Very High
Pancreatic Cancer 116 95.88 Very High Very High Very High
Disease 8 90.40 High High
Calcification 4 81.04 Quite High
Malignant Neoplastic Disease 12 79.48 Quite High
Fibrosis 4 74.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using this method, a significant increase in the ratio of BGLAP/Amy2A mRNA expression in PDAC tissues was observed compared to normal pancreatic tissues.
Positive_regulation (increase) of Transcription (expression) of BGLAP associated with adenocarcinoma
1) Confidence 0.66 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.48 Pain Relevance 0.27
This analysis revealed a significant increase in the mRNA ratio of BGLAP/Amy2A in PDAC (p < 0.0001) compared to normal pancreatic tissues.
Positive_regulation (increase) of Transcription (ratio) of BGLAP associated with adenocarcinoma
2) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.39
As the cellular composition of bulk PDAC and CP tissues is different than that of normal pancreatic tissues, BGLAP mRNA values were normalized to amylase-2A (Amy2A) mRNA levels for each tissue sample to exclude the mRNA expression of BGLAP in the acini (figure 1B).
Positive_regulation (normalized) of Transcription (values) of BGLAP associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.48 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.82 Pain Relevance 0.41
The transcription of BGLAP is dependent on the expression of runx2 transcription factor, which binds to an osteoblast-specific cis-acting element in the promoter of BGLAP [34].
Positive_regulation (dependent) of Transcription (transcription) of BGLAP in osteoblast associated with osteoporosis
4) Confidence 0.44 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox