INT223959

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 15
Disease Relevance 11.25
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Bglap) cytoplasm (Bglap)
Anatomy Link Frequency
osteoblast 4
pancreas 1
adipocytes 1
Bglap (Mus musculus)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 144 97.92 Very High Very High Very High
fibrosis 8 91.36 High High
imagery 32 87.92 High High
cytokine 32 84.56 Quite High
Intracerebroventricular 24 83.36 Quite High
tolerance 18 20.20 Low Low
spastic colon 1 8.48 Low Low
Clonidine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoporosis 50 99.98 Very High Very High Very High
Osteogenic Sarcomas 24 99.84 Very High Very High Very High
Sprains And Strains 58 99.52 Very High Very High Very High
Cancer 120 99.28 Very High Very High Very High
Fetal Diseases 8 98.84 Very High Very High Very High
Adenocarcinoma 248 98.72 Very High Very High Very High
Pancreatitis 144 97.92 Very High Very High Very High
Coagulation Disorder 8 97.80 Very High Very High Very High
Chondrodysplasia 8 96.96 Very High Very High Very High
Obesity 174 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, since cytoplasmic expression of BGLAP was also observed in tubular complexes and cancer cells, it could be speculated that BGLAP is not efficiently released from these cells.
Neg (not) Localization (released) of BGLAP associated with cancer
1) Confidence 0.77 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.19 Pain Relevance 0.14
Interestingly, BGLAP was localized in the tubular complexes and PanIN lesions of both CP and PDAC as well as in the cancer cells in PDAC.
Localization (localized) of BGLAP associated with adenocarcinoma, cancer and chronic pancreatitis
2) Confidence 0.77 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.45 Pain Relevance 0.30
These findings suggest that BGLAP is principally released by acinar cells in the normal and diseased pancreas.
Localization (released) of BGLAP in pancreas
3) Confidence 0.77 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.24 Pain Relevance 0.20
Therefore, and in order to localize BGLAP, immunohistochemistry was performed on pancreatic tissue sections from normal (n = 10), CP (n = 20) and PDAC (n = 20) cases.
Localization (localize) of BGLAP associated with adenocarcinoma and chronic pancreatitis
4) Confidence 0.77 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.27 Pain Relevance 0.44
The slides were then washed in washing buffer (10 mM Tris-HCl, 0.85% NaCl, 0.1% bovine serum albumin, and pH 7.4), and incubated with the mouse monoclonal BGLAP antibody (ZYTOMED Systems GmbH, Berlin, Germany) diluted in a universal block reagent (DAKO Corporation, Carpentaria, CA) for 18 h at 4°C.
Localization (antibody) of BGLAP
5) Confidence 0.71 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0 Pain Relevance 0
Since the discovery of BGLAP secretion in a subset of osteosarcoma cell lines [10], BGLAP has been implicated in the development of various malignant tumors.
Localization (secretion) of BGLAP associated with malignant neoplastic disease and osteogenic sarcomas
6) Confidence 0.67 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.31 Pain Relevance 0
Beyond linking two secreted molecules, i.e., leptin and osteocalcin, these observations establish that the metabolic connection between osteoblasts and adipocytes is tighter than originally thought (Karsenty, 2006; Rosen, 2008).
Localization (secreted) of osteocalcin in adipocytes associated with obesity
7) Confidence 0.66 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.42 Pain Relevance 0
In an islets perifusion assay, 0.03 ng/ml uncarboxylated osteocalcin was a powerful insulin secretagogue (Fig. 3 E) with a strong first phase and a sustained but lower second phase of insulin secretion in all experiments performed (n = 3).
Localization (secretagogue) of osteocalcin
8) Confidence 0.61 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0 Pain Relevance 0.04
In the present study, BGLAP was localized in the acini of normal pancreatic tissues, indicating that the mRNA content of BGLAP represents the acinar fraction in normal pancreatic tissues.
Localization (localized) of BGLAP
9) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.30 Pain Relevance 0.30
BGLAP is a small protein (10.9 kDa) [2] that is secreted by osteosarcoma cells [10] and is involved in bone turn-over of metastatic lesions from tumors such as prostate and breast cancers.
Localization (secreted) of BGLAP associated with cancer, breast cancer and osteogenic sarcomas
10) Confidence 0.59 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 0.95 Pain Relevance 0.21
The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity

The osteoblast-secreted molecule osteocalcin favors insulin secretion, but how this function is regulated in vivo by extracellular signals is for now unknown.

Localization (secreted) of osteocalcin in osteoblast associated with osteoporosis
11) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Title Doc Link PMC2606962 Disease Relevance 0.57 Pain Relevance 0
Osteoblasts secrete osteocalcin, a molecule stimulating ?
Localization (secrete) of osteocalcin in Osteoblasts
12) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.17 Pain Relevance 0.12
It was shown, for instance, that skeleton acts as an endocrine regulator of energy metabolism through the osteoblast-specific secreted molecule osteocalcin that favors insulin secretion by ?
Localization (secreted) of osteocalcin in osteoblast associated with osteoporosis
13) Confidence 0.58 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.18 Pain Relevance 0
These resistances were serially selected in OG1 to provide strain markers [9].
Localization (selected) of OG1 associated with sprains and strains
14) Confidence 0.33 Published 2008 Journal Genome Biol Section Body Doc Link PMC2530867 Disease Relevance 0.78 Pain Relevance 0
Beyond linking two secreted molecules, i.e., leptin and osteocalcin, these observations establish that the metabolic connection between osteoblasts and adipocytes is tighter than originally thought (Karsenty, 2006; Rosen, 2008).
Localization (secreted) of osteocalcin in osteoblasts associated with obesity
15) Confidence 0.22 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2606962 Disease Relevance 0.42 Pain Relevance 0

General Comments

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