INT223960

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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 4.88
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (AMY2A) small molecule metabolic process (AMY2A) hydrolase activity, acting on glycosyl bonds (AMY2A)
extracellular region (AMY2A) carbohydrate metabolic process (AMY2A)
AMY2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 54 98.30 Very High Very High Very High
fibrosis 3 74.24 Quite High
cytokine 12 37.44 Quite Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 93 99.84 Very High Very High Very High
Pancreatitis 54 98.30 Very High Very High Very High
Cancer 45 94.40 High High
Disease 6 90.40 High High
Calcification 3 80.12 Quite High
Malignant Neoplastic Disease 9 79.48 Quite High
Fibrosis 3 74.24 Quite High
Pancreatic Cancer 87 73.88 Quite High
Metastasis 15 73.04 Quite High
Breast Cancer 6 67.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This analysis revealed a significant increase in the mRNA ratio of BGLAP/Amy2A in PDAC (p < 0.0001) compared to normal pancreatic tissues.
Positive_regulation (increase) of Transcription (ratio) of Amy2A associated with adenocarcinoma
1) Confidence 0.08 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.63 Pain Relevance 0.39
Using this method, a significant increase in the ratio of BGLAP/Amy2A mRNA expression in PDAC tissues was observed compared to normal pancreatic tissues.
Positive_regulation (increase) of Transcription (expression) of Amy2A associated with adenocarcinoma
2) Confidence 0.08 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.48 Pain Relevance 0.27
As the cellular composition of bulk PDAC and CP tissues is different than that of normal pancreatic tissues, BGLAP mRNA values were normalized to amylase-2A (Amy2A) mRNA levels for each tissue sample to exclude the mRNA expression of BGLAP in the acini (figure 1B).
Positive_regulation (normalized) of Transcription (levels) of Amy2A associated with adenocarcinoma and chronic pancreatitis
3) Confidence 0.08 Published 2007 Journal Mol Cancer Section Body Doc Link PMC2245975 Disease Relevance 1.77 Pain Relevance 0.41

General Comments

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