INT224005

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Context Info
Confidence 0.40
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.48
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
blood vessels 2
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 52 98.92 Very High Very High Very High
cytokine 5 65.56 Quite High
antagonist 23 5.00 Very Low Very Low Very Low
Inflammation 21 5.00 Very Low Very Low Very Low
adenocard 17 5.00 Very Low Very Low Very Low
noradrenaline 9 5.00 Very Low Very Low Very Low
Pain 9 5.00 Very Low Very Low Very Low
Migraine 8 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
aspirin 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 18 99.98 Very High Very High Very High
Targeted Disruption 17 82.00 Quite High
Neointima 5 75.68 Quite High
Increased Venous Pressure Under Development 61 71.84 Quite High
Cv Unclassified Under Development 9 58.72 Quite High
Hypertension 24 28.52 Quite Low
Hypoxia 6 26.32 Quite Low
Disease 12 25.00 Low Low
Diabetes Mellitus 11 24.12 Low Low
Cardiovascular Disease 11 23.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell surface expression of the P2X1 receptor was also unaffected by cholesterol disruption (Fig. 3a, lower panel) demonstrating that a change in receptor number does not account for the inhibition of P2X1 receptor responses.
Neg (unaffected) Negative_regulation (unaffected) of Gene_expression (expression) of P2X1 receptor
1) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.09
for the equivalent P2X1 receptor region reduced the effects of cholesterol depletion by ?
Negative_regulation (reduced) of Gene_expression (region) of P2X1 receptor
2) Confidence 0.40 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
In intact human blood vessels examined in vitro, shear stress decreased contractile P2X1 receptor expression, but increased the expression of mitogenic P2Y2 and P2Y6 receptors in VSMC [151].
Negative_regulation (decreased) of Gene_expression (expression) of P2X1 receptor in blood vessels associated with stress
3) Confidence 0.35 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 0.48 Pain Relevance 0.03
M, a maximal concentration; Roberts and Evans, 2004) evoked P2X1 receptor currents (?
Negative_regulation (evoked) of Gene_expression (currents) of P2X1 receptor
4) Confidence 0.33 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.04

General Comments

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