INT224011

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Context Info
Confidence 0.45
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 10
Disease Relevance 1.12
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (P2RX1) transport (P2RX1) plasma membrane (P2RX1)
protein complex (P2RX1)
Anatomy Link Frequency
TM1 1
endothelium 1
P2RX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 145 99.98 Very High Very High Very High
potassium channel 5 96.76 Very High Very High Very High
adenocard 30 93.52 High High
antagonist 36 86.88 High High
noradrenaline 9 60.76 Quite High
Kinase C 9 25.60 Quite Low
Inflammation 21 5.00 Very Low Very Low Very Low
Pain 15 5.00 Very Low Very Low Very Low
Migraine 8 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 2 99.12 Very High Very High Very High
Stress 20 98.78 Very High Very High Very High
Increased Venous Pressure Under Development 61 93.32 High High
Hypertension 24 85.76 High High
Targeted Disruption 19 82.24 Quite High
Pre-eclampsia 1 67.12 Quite High
Stroke 7 59.00 Quite High
Leukemia 1 51.20 Quite High
Helminth Infection 3 19.40 Low Low
Myocardial Infarction 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The P2X2 receptor was associated with flotillin for extraction in 0.1 and 0.3% Triton, but when this was increased to 1%, P2X2 moved to the non-raft fractions and was below the limit of detection in the lipid raft fractions (Fig. 2).
P2X2 receptor Binding (associated) of
1) Confidence 0.45 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0
It confirms the identification of 2-azido ATP as a cross-linking compound which directly binds to the P2X1 receptor.


P2X1 receptor Binding (binds) of
2) Confidence 0.37 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0
This suggests that the pre-TM1 region of the receptor plays a role in the regulation of the opening of agonist-bound P2X1 receptors, i.e. an effect on channel gating.
P2X1 Binding (bound) of in TM1 associated with agonist
3) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.14
We have therefore compared the raft association of P2X1-4 receptors following solubilization in 0.1, 0.3, and 1% Triton X-100.
P2X1 Binding (association) of
4) Confidence 0.35 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.03
PIP2 binds to the P2X1 receptor at the intracellular carboxyl terminus close to TM2, and P2X1 receptor currents were inhibited following PIP2 depletion with wortmannin (44), raising the possibility that this region may contribute to cholesterol sensitivity.
P2X1 receptor Binding (binds) of
5) Confidence 0.33 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963349 Disease Relevance 0 Pain Relevance 0.05
The reactive side groups of these substituted ATP analogues cross-link to the P2X receptor at sites that are likely to be close to those involved in ATP binding.
P2X receptor Binding (link) of
6) Confidence 0.29 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.14
The cross-linking of 2-azido ATP and the P2X1 receptor was tested using a radiolabelling assay.
P2X1 receptor Binding (linking) of
7) Confidence 0.29 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0.09
To reduce non-specific binding the cross-linked P2X1 receptor was isolated by immunoprecipitation with the P2X1 antibody and the samples were run on a 10% SDS gel.
P2X1 receptor Binding (binding) of
8) Confidence 0.27 Published 2009 Journal Neuropharmacology Section Body Doc Link PMC2613953 Disease Relevance 0 Pain Relevance 0
It is released upon stimulation of the endothelium by acetylcholine, thrombin and mechanical stress and can be cleaved into either ATP or UTP to stimulate both P2X1 and P2Y2 receptors on VSMC resulting in increased blood pressure [88].
P2X1 Binding (receptors) of in endothelium associated with stress and pressure and volume under development
9) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245998 Disease Relevance 1.07 Pain Relevance 0.07
The purpose of the present work was to determine whether the O. tauri sequence encodes a functioning P2X receptor and, if so, to investigate its properties.
P2X receptor Binding (investigate) of
10) Confidence 0.05 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0.05 Pain Relevance 0.09

General Comments

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