INT22404

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.39
First Reported 1983
Last Reported 2008
Negated 4
Speculated 2
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 3.66
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (DBI) transport (DBI)
Anatomy Link Frequency
plasma 4
muscle cell 1
oviduct 1
DBI (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 23 100.00 Very High Very High Very High
Endogenous opioid 1 100.00 Very High Very High Very High
antagonist 13 99.42 Very High Very High Very High
Hyperalgesia 8 99.08 Very High Very High Very High
allodynia 5 98.40 Very High Very High Very High
Serotonin 8 98.34 Very High Very High Very High
anesthesia 4 97.24 Very High Very High Very High
epidural 5 97.02 Very High Very High Very High
Pain 21 95.60 Very High Very High Very High
Neurotransmitter 1 93.60 High High
Disease Link Frequency Relevance Heat
Ectopic Pregnancy 190 100.00 Very High Very High Very High
Chlamydia Infection 4 100.00 Very High Very High Very High
Starvation 1 100.00 Very High Very High Very High
Hyperalgesia 10 99.08 Very High Very High Very High
Obesity 11 98.50 Very High Very High Very High
Neuropathic Pain 15 98.40 Very High Very High Very High
Pain 13 95.60 Very High Very High Very High
Hypoglycemia 4 94.48 High High
Hypoxia 4 93.32 High High
Appendicitis 4 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: The patch delivery of DI in DI-EP affords controlled delivery of the active drug in contrast to that from application of gels or ointments of NSAIDs.


Regulation (controlled) of DI-EP
1) Confidence 0.39 Published 2008 Journal Curr Med Res Opin Section Body Doc Link 18814824 Disease Relevance 0 Pain Relevance 0
A pharmacological approach was used to investigate the serotoninergic control of plasma levels on beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) in humans.
Spec (investigate) Regulation (control) of beta-EP in plasma
2) Confidence 0.26 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.18
Pretreatment with methysergide, a SE receptor antagonist (3 X 2.8 mg orally, five men), did not induce any significant changes in plasma beta-EP and beta-LPH levels, but blocked the increase in the two hormones evoked by L5-OH-triptophan (40 mg iv).
Neg (not) Regulation (changes) of beta-EP in plasma associated with antagonist and serotonin
3) Confidence 0.23 Published 1984 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6092410 Disease Relevance 0 Pain Relevance 0.33
In the 13 patients in labor who underwent epidural anesthesia, plasma beta-EP concentrations decreased (P less than 0.005) from 54.5 +/- 9.0 to 28.2 +/- 3.5 fmol/ml, whereas there was no significant change in plasma beta-EP levels in the 10 controls who averaged 64 +/- 20.5 and 55.8 +/- 13.6 fmol/ml prior to and following saline injection.
Neg (no) Regulation (change) of beta-EP in plasma associated with anesthesia and epidural
4) Confidence 0.22 Published 1983 Journal Anesthesiology Section Abstract Doc Link 6305238 Disease Relevance 0 Pain Relevance 0.57
In obese adolescents, in spite of the normal rhythm of beta LPH and cortisol, beta EP levels did not change throughout the day, thus suggesting beta EP secretion from nonpituitary sources in these subjects.
Neg (not) Regulation (change) of EP associated with obesity
5) Confidence 0.18 Published 1986 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 2933422 Disease Relevance 0.78 Pain Relevance 0
The implantation environment in the oviduct is very different from that of the well-vascularized endometrium, and production and secretion of VEGF may be affected in EP.
Spec (may) Regulation (affected) of EP in oviduct associated with ectopic pregnancy
6) Confidence 0.11 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 0.65 Pain Relevance 0.04
The trophoblast usually invades the muscle layer and maternal blood vessels are eroded, allowing muscle cell products such as CK to enter the circulation;26 therefore, increased serum CK levels are normal during EP.26,27 The pathology of arrested IUP and pelvic inflammatory disease are different, although both demonstrate no change in CK concentration.
Neg (no) Regulation (change) of EP in muscle cell associated with inflammation, chlamydia infection and ectopic pregnancy
7) Confidence 0.08 Published 2008 Journal Clinics Section Body Doc Link PMC2664731 Disease Relevance 1.22 Pain Relevance 0.08
To identify the effects of acute starvation on endogenous opioids in man, plasma beta-endorphin (beta-EP) was measured in 17 patients before, during and after fasting.
Regulation (effects) of beta-EP in plasma associated with starvation and endogenous opioid
8) Confidence 0.05 Published 1990 Journal Horm. Res. Section Abstract Doc Link 2289782 Disease Relevance 0.10 Pain Relevance 0.10
EP receptor antagonists have provided evidence of a role for EP receptors in reducing hyperalgesia and allodynia in rodents [20].
Regulation (role) of EP associated with hyperalgesia, allodynia and antagonist
9) Confidence 0.03 Published 2006 Journal BMC Neurol Section Body Doc Link PMC1361784 Disease Relevance 0.84 Pain Relevance 0.94

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox