INT224042

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.25
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Anatomy Link Frequency
NG108-15 2
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 515 99.82 Very High Very High Very High
adenocard 300 96.52 Very High Very High Very High
antagonist 85 81.12 Quite High
Inflammation 20 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
Thalamus 10 5.00 Very Low Very Low Very Low
Hippocampus 10 5.00 Very Low Very Low Very Low
Cannabinoid 10 5.00 Very Low Very Low Very Low
cerebral cortex 5 5.00 Very Low Very Low Very Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anaplastic Astrocytoma 15 91.92 High High
Disease 30 73.84 Quite High
Cancer 55 38.56 Quite Low
Necrosis 5 38.00 Quite Low
Increased Venous Pressure Under Development 15 18.56 Low Low
Vibrio Infection 10 11.20 Low Low
Hypoxia 25 5.00 Very Low Very Low Very Low
Obesity 20 5.00 Very Low Very Low Very Low
INFLAMMATION 20 5.00 Very Low Very Low Very Low
Neuroblastoma 20 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The role of GRK2 in agonist-induced phosphorylation and subsequent desensitization of A2AR and A2BR was thoroughly investigated by Kelly and co-workers.
Phosphorylation (phosphorylation) of A2BR associated with agonist
1) Confidence 0.29 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.16
The A2BR, endogenously expressed in NG108-15 cells, is desensitized through phosphorylation by GRK2.
Phosphorylation (phosphorylation) of A2BR in NG108-15
2) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.23
They concluded that these second messenger-dependent kinases are not involved in A2BR phosphorylation [80].
Phosphorylation (phosphorylation) of A2BR
3) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.09 Pain Relevance 0.18
For instance, the A1Rs are not (readily) phosphorylated and internalize slowly, showing a typical half-life of several hours, whereas the A2AR and A2BR undergo much faster downregulation, usually shorter than 1 h.
Neg (not) Phosphorylation (phosphorylated) of A2BR
4) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2245999 Disease Relevance 0.07 Pain Relevance 0.32
A similar conclusion for A2BR phosphorylation in NG108-15 cells was reached by Mundell and Kelly [61].
Phosphorylation (phosphorylation) of A2BR in NG108-15
5) Confidence 0.22 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.09 Pain Relevance 0.18

General Comments

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