INT224047

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2007
Last Reported 2008
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.23
Pain Relevance 2.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Adora2b) plasma membrane (Adora2b) signal transducer activity (Adora2b)
Anatomy Link Frequency
aorta 1
Adora2b (Mus musculus)
Pain Link Frequency Relevance Heat
adenocard 353 99.78 Very High Very High Very High
ischemia 285 99.44 Very High Very High Very High
agonist 314 94.40 High High
Analgesic 1 93.52 High High
IPN 1 92.76 High High
antagonist 62 83.36 Quite High
Inflammation 124 83.28 Quite High
cytokine 19 82.24 Quite High
Inflammatory response 6 69.20 Quite High
Kinase C 6 11.28 Low Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 276 99.44 Very High Very High Very High
Inflammatory Pain 1 92.76 High High
Increased Venous Pressure Under Development 21 92.28 High High
Injury 35 91.60 High High
Coronary Artery Disease 5 85.84 High High
INFLAMMATION 126 83.28 Quite High
Hypoxia 36 81.28 Quite High
Necrosis 20 77.52 Quite High
Anaplastic Astrocytoma 6 72.08 Quite High
Adhesions 5 67.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Adenosine-mediated vasorelaxation in mouse aorta is partially dependent on A2B AR [52], and A2B ARs mediate relaxation in human small resistance-like coronary arteries, which is independent of nitric oxide (NO) but partly coupled to potassium (K+) channel function [53].
Spec (partially) Regulation (dependent) of A2B in aorta associated with adenocard
1) Confidence 0.27 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2583210 Disease Relevance 0.81 Pain Relevance 0.36
Taken together, these data provide what we believe to be a previously not appreciated role of reno-vascular A2BAR signaling in enhancing renal resistance to ischemia and provide strong rationale for therapeutically targeting the A2BAR during renal ischemia.
Regulation (targeting) of A2BAR associated with ischemia
2) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.65 Pain Relevance 0.40
Taken together, these studies provide strong rationale for therapeutically targeting the A2BAR during renal ischemia.


Regulation (targeting) of A2BAR associated with ischemia
3) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.45 Pain Relevance 0.16
These results identify the A2BAR as a novel therapeutic target for providing potent protection from renal ischemia.



Regulation (target) of A2BAR associated with ischemia
4) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504049 Disease Relevance 0.60 Pain Relevance 0.50
Deleting the final two amino acids (Leu330-stop) did not affect the internalization properties of the A2BR.
Neg (not) Regulation (affect) of A2BR
5) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.14 Pain Relevance 0.15
However, whereas applying NECA to the apical side of the membrane had no effect on the basolateral A2BR, basolateral NECA induced a complete desensitization of the apical receptor.
Neg (no) Regulation (effect) of A2BR
6) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0.13 Pain Relevance 0.06
The adenosine receptor, Adora2b was also strongly induced by LPS in BMM (191-fold at 6 h) yet was only modestly regulated (3-fold at 7 h) in TEPM.
Regulation (regulated) of Adora2b associated with adenocard
7) Confidence 0.09 Published 2008 Journal Immunome Res Section Body Doc Link PMC2394514 Disease Relevance 0.45 Pain Relevance 0.48

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox