INT22409

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Context Info
Confidence 0.30
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.53
Pain Relevance 1.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tbxa2r) plasma membrane (Tbxa2r) signal transducer activity (Tbxa2r)
Anatomy Link Frequency
platelet 6
endothelial cells 2
Tbxa2r (Mus musculus)
Pain Link Frequency Relevance Heat
Angina 9 97.64 Very High Very High Very High
agonist 22 96.40 Very High Very High Very High
aspirin 58 96.20 Very High Very High Very High
Serotonin 2 92.96 High High
antagonist 5 92.88 High High
ischemia 2 90.96 High High
Inflammation 5 86.28 High High
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 64 98.52 Very High Very High Very High
Cv General 3 Under Development 9 97.64 Very High Very High Very High
Myocardial Infarction 6 93.44 High High
Coronary Artery Disease 4 93.20 High High
Increased Venous Pressure Under Development 3 91.84 High High
INFLAMMATION 5 86.28 High High
Atherosclerotic Plaque 4 57.24 Quite High
Stress 24 50.00 Quite Low
Cardiovascular Disease 9 42.48 Quite Low
Necrosis 1 26.40 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of U46619, a thromboxane A2 mimetic, and 8-iso PGF2?
Regulation (effects) of Gene_expression (mimetic) of thromboxane A2
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2939892 Disease Relevance 0 Pain Relevance 0.18
Moreover Gresele et al (1989) showed that picotamide, apart from reducing the synthesis of TxA2, enhanced the formation of PGE2 in platelets and favored the formation of PGI2 by aspirinated endothelial cells.
Regulation (reducing) of Gene_expression (synthesis) of TxA2 in endothelial cells
2) Confidence 0.27 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0 Pain Relevance 0.10
The eicosapentaenic acid (EPA)-rich diet containing precursors of inactive TxA2 synthesis and the routine hospital diet (No. 10 according to Pevzner) were examined for effects on platelet generation of TxA2 on induction of ADP aggregation in 12 patients with first angina (FA).
Spec (examined) Regulation (effects) of Gene_expression (generation) of TxA2 in platelet associated with angina
3) Confidence 0.26 Published 1990 Journal Kardiologiia Section Abstract Doc Link 2290264 Disease Relevance 0.55 Pain Relevance 0.42
This elevation of TXB2 was supposed to be derived from platelet activation in coronary circulation due to altered production of TXA2 and prostacyclin (PGI2).
Regulation (altered) of Gene_expression (production) of TXA2 in platelet
4) Confidence 0.21 Published 1988 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 3137347 Disease Relevance 0.44 Pain Relevance 0.22
Diabetes is a clinical setting characterized by enhanced platelet activation that depends in part on increased platelet production of thromboxane A2.
Regulation (depends) of Gene_expression (production) of thromboxane A2 in platelet associated with diabetes mellitus
5) Confidence 0.14 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994050 Disease Relevance 0.54 Pain Relevance 0.22

General Comments

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