INT224109

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Context Info
Confidence 0.52
First Reported 2007
Last Reported 2007
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.07
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adora2a) enzyme binding (Adora2a) signal transducer activity (Adora2a)
Adora2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 309 99.82 Very High Very High Very High
adenocard 180 96.52 Very High Very High Very High
antagonist 51 80.40 Quite High
Inflammation 12 5.00 Very Low Very Low Very Low
Spinal cord 6 5.00 Very Low Very Low Very Low
Thalamus 6 5.00 Very Low Very Low Very Low
Hippocampus 6 5.00 Very Low Very Low Very Low
Cannabinoid 6 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 18 73.84 Quite High
Cancer 33 37.84 Quite Low
Necrosis 3 37.28 Quite Low
Hypoxia 15 5.00 Very Low Very Low Very Low
Obesity 12 5.00 Very Low Very Low Very Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low
Neuroblastoma 12 5.00 Very Low Very Low Very Low
Anaplastic Astrocytoma 9 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 9 5.00 Very Low Very Low Very Low
Bordatella Infection 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Which GRK isoforms are involved in the phosphorylation of the A2AR is not entirely clear yet.
Phosphorylation (phosphorylation) of A2AR
1) Confidence 0.52 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.21
The role of GRK2 in agonist-induced phosphorylation and subsequent desensitization of A2AR and A2BR was thoroughly investigated by Kelly and co-workers.
Phosphorylation (phosphorylation) of A2AR associated with agonist
2) Confidence 0.52 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2245999 Disease Relevance 0 Pain Relevance 0.16
For instance, the A1Rs are not (readily) phosphorylated and internalize slowly, showing a typical half-life of several hours, whereas the A2AR and A2BR undergo much faster downregulation, usually shorter than 1 h.
Neg (not) Phosphorylation (phosphorylated) of A2AR
3) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Abstract Doc Link PMC2245999 Disease Relevance 0.07 Pain Relevance 0.32

General Comments

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